Anti-obesity and anti-adipogenic effects of chitosan oligosaccharide (GO2KA1) in SD rats and in 3T3-L1 preadipocytes models

JY Lee, TY Kim, H Kang, J Oh, JW Park, SC Kim, M Kim… - Molecules, 2021 - mdpi.com
Excess body weight is a major risk factor for type 2 diabetes (T2D) and associated metabolic
complications, and weight loss has been shown to improve glycemic control and decrease …

Antidiabetic effect of chitosan oligosaccharide (GO2KA1) is mediated via inhibition of intestinal alpha‐glucosidase and glucose transporters and PPARγ expression

SY Yu, YI Kwon, C Lee, E Apostolidis, YC Kim - BioFactors, 2017 - Wiley Online Library
We have previously reported that administration of low molecular weight chitosan
oligosaccharide (GO2KA1) significantly suppressed postprandial blood glucose rise with …

Effect of long-term supplementation of low molecular weight chitosan oligosaccharide (GO2KA1) on fasting blood glucose and HbA1c in db/db mice model and …

JG Kim, SH Jo, KS Ha, SC Kim, YC Kim… - … and Alternative Medicine, 2014 - Springer
Background Type 2 diabetes is a serious problem for developed countries. Prevention of
prediabetes progression to type 2 diabetes with the use of natural products appears to a cost …

The effects of chitosan oligosaccharide (GO2KA1) supplementation on glucose control in subjects with prediabetes

HJ Kim, HY Ahn, JH Kwak, DY Shin, YI Kwon, CG Oh… - Food & function, 2014 - pubs.rsc.org
We aimed to evaluate the effect of chitosan oligosaccharide (GO2KA1) supplementation on
glucose control in subjects with prediabetes. This study was a randomized, double-blind …

[PDF][PDF] Chitosan oligosaccharides inhibit adipogenesis in 3T3-L1 adipocytes

EJ Cho, A Rahman, SW Kim, YM Baek, HJ Hwang… - J. Microbiol …, 2008 - jmb.or.kr
The 3T3-L1 cell line is a well-established and commonly used in vitro model to assess
adipocyte differentiation. Over the course of several days, confluent 3T3-L1 cells can be …

Molecular weight dependent glucose lowering effect of low molecular weight chitosan oligosaccharide (GO2KA1) on postprandial blood glucose level in SD rats …

SH Jo, KS Ha, KS Moon, JG Kim, CG Oh… - International Journal of …, 2013 - mdpi.com
This research investigated the effect of enzymatically digested low molecular weight (MW)
chitosan oligosaccharide on type 2 diabetes prevention. Three different chitosan …

Anti-obesity effects of galacto-oligosaccharides in obese rats

S Kong, X Huang, H Cao, Y Bai, Q Che, H Nie… - European Journal of …, 2022 - Elsevier
Galacto-oligosaccharides (GOS) are commonly used as prebiotic with a variety of known
metabolic benefits; however, whether GOS plays a protective role in obesity remains …

Proteomic analysis for inhibitory effect of chitosan oligosaccharides on 3T3‐L1 adipocyte differentiation

MA Rahman, SG Kumar, SW Kim, HJ Hwang… - …, 2008 - Wiley Online Library
In the present study, we performed a differential proteomic analysis using 2‐DE combined
with MS to clarify the molecular mechanism for the suppressive effect of chitosan …

Sulfation of chitosan oligomers enhances their anti-adipogenic effect in 3T3-L1 adipocytes

F Karadeniz, MZ Karagozlu, SY Pyun, SK Kim - Carbohydrate Polymers, 2011 - Elsevier
Inhibition of adipogenesis and lipid accumulation has a very crucial role to prevent obesity.
Low molecular weight (LMW) chitosan is known to inhibit fat accumulation and …

Fucoidan, a sulfated polysaccharide, inhibits adipogenesis through the mitogen-activated protein kinase pathway in 3T3-L1 preadipocytes

KJ Kim, OH Lee, BY Lee - Life sciences, 2010 - Elsevier
AIMS: Fucoidan, consisting of l-fucose together with xylose, galactose and mannose, is a
sulfated polysaccharide from brown seaweeds, which has been reported to affect the …