Parasites of the Leishmania genus are the causative agents of leishmaniasis in humans, a
disease that affects more than 12 million people worldwide. These parasites replicate …

Leishmaniasis is a major tropical disease that can present with cutaneous, mucocutaneous,
or visceral manifestation and affects millions of individuals, causing substantial morbidity …

Protozoan parasites of the genus Leishmania are the causative agents of Leishmaniasis, a
disease that can be lethal and affects 12 million people worldwide. Leishmania replicates …

Parasites of the Leishmania genus infect and survive within macrophages by inhibiting
several microbicidal molecules, such as nitric oxide and pro-inflammatory cytokines. In this …

Activation of the NLRP3 inflammasome by Leishmania parasites is critical for the outcome of
leishmaniasis, a disease that affects millions of people worldwide. We investigate the …

Leishmania RNA virus (LRV) is an important virulence factor associated with the
development of mucocutaneous Leishmaniasis, a severe form of the disease. LRV-mediated …

Deregulated CD8+ T cell cytotoxicity plays a central role in enhancing disease severity in
several conditions. However, we have little understanding of the mechanisms by which …

Induction of immunity that limits Toxoplasma gondii infection in mice is critically dependent
on the activation of the innate immune response. In this study, we investigated the role of …

Infection of C57BL/6 mice with most Leishmania major strains results in a healing lesion and
clearance of parasites from the skin. Infection of C57BL/6 mice with the L. major Seidman …

Type 2 nitric oxide synthase (NOS2) is required for the Th1-dependent healing of infections
with intracellular microbes, including Leishmania major. Here, we demonstrate the …