Control of Leishmania major infection in mice lacking TNF receptors
M Nashleanas, S Kanaly, P Scott - The Journal of Immunology, 1998 - journals.aai.org
TNF participates in the induction of nitric oxide (NO) production and macrophage activation,
leading to the elimination of intracellular pathogens. We previously found that TNF receptor …
leading to the elimination of intracellular pathogens. We previously found that TNF receptor …
Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthase.
S Stenger, N Donhauser, H Thüring… - The Journal of …, 1996 - rupress.org
Nitric oxide (NO) synthase (iNOS) is required for the resolution of acute cutaneous
leishmaniasis in resistant C57BL/6 mice. As is the case in several other infections, the …
leishmaniasis in resistant C57BL/6 mice. As is the case in several other infections, the …
NLR proteins and parasitic disease
Parasitic diseases are a serious global health concern. Many of the most common and most
severe parasitic diseases, including Chagas' disease, leishmaniasis, and schistosomiasis …
severe parasitic diseases, including Chagas' disease, leishmaniasis, and schistosomiasis …
A novel form of NF‐κB is induced by Leishmania infection: Involvement in macrophage gene expression
DJ Gregory, M Godbout, I Contreras… - European journal of …, 2008 - Wiley Online Library
Leishmania spp. are obligate intracellular parasites that inhabit the phagolysosomes of
macrophages. Manipulation of host cell signaling pathways and gene expression by …
macrophages. Manipulation of host cell signaling pathways and gene expression by …
Leishmania major Attenuates Host Immunity by Stimulating Local Indoleamine 2,3-Dioxygenase Expression
LHC Makala, B Baban, H Lemos… - Journal of Infectious …, 2011 - academic.oup.com
Inflammation stimulates immunity but can create immune privilege in some settings. Here,
we show that cutaneous Leishmania major infection stimulated expression of the immune …
we show that cutaneous Leishmania major infection stimulated expression of the immune …
Transcriptional profiling in experimental visceral leishmaniasis reveals a broad splenic inflammatory environment that conditions macrophages toward a disease …
F Kong, OA Saldarriaga, H Spratt, EY Osorio… - PLoS …, 2017 - journals.plos.org
Visceral Leishmaniasis (VL), caused by the intracellular protozoan Leishmania donovani, is
characterized by relentlessly increasing visceral parasite replication, cachexia, massive …
characterized by relentlessly increasing visceral parasite replication, cachexia, massive …
The role of nitric oxide in innate immunity.
C Bogdan, M Röllinghoff, A Diefenbach - Immunological reviews, 2000 - europepmc.org
Type 2 nitric oxide synthase (iNOS or NOS2) was originally described as an enzyme that is
expressed in activated macrophages, generates nitric oxide (NO) from the amino acid L …
expressed in activated macrophages, generates nitric oxide (NO) from the amino acid L …
Cytokines and nitric oxide as effector molecules against parasitic infections
Nitric oxide (NO) derived from L–arginine by the catalytic action of inducible NO synthase
(iNOS) plays an important role in killing parasites. Many cell types express high levels of …
(iNOS) plays an important role in killing parasites. Many cell types express high levels of …
Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses
Macrophages play host to Leishmania major, a parasite that causes leishmaniasis in
500,000 people annually. Macrophage-expressed CD40, a costimulatory molecule, induces …
500,000 people annually. Macrophage-expressed CD40, a costimulatory molecule, induces …
NLRP3 inflammasome in cancer and metabolic diseases
BR Sharma, TD Kanneganti - Nature immunology, 2021 - nature.com
The NLRP3 inflammasome is a multimeric cytosolic protein complex that assembles in
response to cellular perturbations. This assembly leads to the activation of caspase-1, which …
response to cellular perturbations. This assembly leads to the activation of caspase-1, which …