Control of Leishmania major infection in mice lacking TNF receptors

M Nashleanas, S Kanaly, P Scott - The Journal of Immunology, 1998 - journals.aai.org
TNF participates in the induction of nitric oxide (NO) production and macrophage activation,
leading to the elimination of intracellular pathogens. We previously found that TNF receptor …

Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthase.

S Stenger, N Donhauser, H Thüring… - The Journal of …, 1996 - rupress.org
Nitric oxide (NO) synthase (iNOS) is required for the resolution of acute cutaneous
leishmaniasis in resistant C57BL/6 mice. As is the case in several other infections, the …

NLR proteins and parasitic disease

GM Clay, FS Sutterwala, ME Wilson - Immunologic research, 2014 - Springer
Parasitic diseases are a serious global health concern. Many of the most common and most
severe parasitic diseases, including Chagas' disease, leishmaniasis, and schistosomiasis …

A novel form of NF‐κB is induced by Leishmania infection: Involvement in macrophage gene expression

DJ Gregory, M Godbout, I Contreras… - European journal of …, 2008 - Wiley Online Library
Leishmania spp. are obligate intracellular parasites that inhabit the phagolysosomes of
macrophages. Manipulation of host cell signaling pathways and gene expression by …

Leishmania major Attenuates Host Immunity by Stimulating Local Indoleamine 2,3-Dioxygenase Expression

LHC Makala, B Baban, H Lemos… - Journal of Infectious …, 2011 - academic.oup.com
Inflammation stimulates immunity but can create immune privilege in some settings. Here,
we show that cutaneous Leishmania major infection stimulated expression of the immune …

Transcriptional profiling in experimental visceral leishmaniasis reveals a broad splenic inflammatory environment that conditions macrophages toward a disease …

F Kong, OA Saldarriaga, H Spratt, EY Osorio… - PLoS …, 2017 - journals.plos.org
Visceral Leishmaniasis (VL), caused by the intracellular protozoan Leishmania donovani, is
characterized by relentlessly increasing visceral parasite replication, cachexia, massive …

The role of nitric oxide in innate immunity.

C Bogdan, M Röllinghoff, A Diefenbach - Immunological reviews, 2000 - europepmc.org
Type 2 nitric oxide synthase (iNOS or NOS2) was originally described as an enzyme that is
expressed in activated macrophages, generates nitric oxide (NO) from the amino acid L …

Cytokines and nitric oxide as effector molecules against parasitic infections

FY Liew, XQ Wei, L Proudfoot - … Transactions of the …, 1997 - royalsocietypublishing.org
Nitric oxide (NO) derived from L–arginine by the catalytic action of inducible NO synthase
(iNOS) plays an important role in killing parasites. Many cell types express high levels of …

Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses

RK Mathur, A Awasthi, P Wadhone, B Ramanamurthy… - Nature medicine, 2004 - nature.com
Macrophages play host to Leishmania major, a parasite that causes leishmaniasis in
500,000 people annually. Macrophage-expressed CD40, a costimulatory molecule, induces …

NLRP3 inflammasome in cancer and metabolic diseases

BR Sharma, TD Kanneganti - Nature immunology, 2021 - nature.com
The NLRP3 inflammasome is a multimeric cytosolic protein complex that assembles in
response to cellular perturbations. This assembly leads to the activation of caspase-1, which …