NLRP3 forms an inflammasome with its adaptor ASC, and its excessive activation can cause
inflammatory diseases. However, little is known about the mechanisms that control assembly …

In order to survive within the macrophages of its host organism, the protozoan parasite
Leishmania inhibits a number of critical, gamma interferon (IFN-γ)-inducible, macrophage …

Inflammation is a protective attempt by the host to remove injurious stimuli and initiate the
tissue healing process. The inflammatory response must be actively terminated, however …

The host response to Leishmania infection is regulated by a specific pattern of local cytokine
production. We investigated the effect of interleukin (IL)‐10 and IL‐4 on the leishmanicidal …

Type I IFNs exert diverse effector and regulatory functions in host immunity to viral and
nonviral infections; however, the role of endogenous type I IFNs in leishmaniasis is unclear …

To discover how nitric oxide (NO) synthesis is controlled in different tissues as cells within
these tissues combat intracellular pathogens, we examined three distinctively different …

The protective immune response to intracellular parasites involves in most cases the
differentiation of IFNγ-secreting CD4+ T helper (Th) 1 cells. Notch receptors regulate cell …

Leishmania chagasi, the cause of South American visceral leishmaniasis, must survive
antimicrobial responses of host macrophages to establish infection. Macrophage oxidative …

We investigated the role of neutrophil elastase (NE) in interactions between murine
inflammatory neutrophils and macrophages infected with the parasite Leishmania major. A …

Inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production was
demonstrated in J774-G8 macrophages infected with Leishmania (L.) amazonensis …