The fact that not all individuals exposed to the same environmental risk factors develop
obesity supports the hypothesis of the existence of underlying genetic and epigenetic …

Background: Recent technological advances in epigenome profiling have led to an
increasing number of studies investigating the role of the epigenome in obesity. There is …

The etiology of obesity is multifactorial, involving complex interactions among the genetic
makeup, neuroendocrine status, fetal programming, and different unhealthy environmental …

To elucidate the mechanisms related to the development of type 2 diabetes (T2D) and other
degenerative diseases at a molecular level, a better understanding of the changes in the …

DNA methylation is a major epigenetic modification that controls gene expression in
physiologic and pathologic states. Metabolic diseases such as diabetes and obesity are …

DNA methylation is implicated in tissue-specific gene expression and genomic imprinting. It
is modulated by environmental factors, especially nutrition. Modified DNA methylation …

Obesity is a worldwide epidemic and contributes to global morbidity and mortality mediated
via the development of nonalcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D) …

The combination of the obesity epidemic and an aging population presents growing
challenges for the healthcare system. Obesity and aging are major risk factors for a diverse …

Background The current epidemic of obesity and associated diseases calls for swift actions
to better understand the mechanisms by which genetics and environmental factors affect …

Epigenetics could help to explain individual differences in weight loss after an energy‐
restriction intervention. Here, we identify novel potential epigenetic biomarkers of weight …