This review describes a series of animal experiments that investigate the role of
endogenous adenosine (AD) in sleep. We propose that AD is a modulator of the sleepiness …

Adenosine has been proposed as a homeostatic “sleep factor” that promotes the transition
from waking to sleep by affecting several sleep–wake regulatory systems. In the basal …

It is currently hypothesized that the drive to sleep is determined by the activity of the basal
forebrain (BF) cholinergic neurons, which release adenosine (AD), perhaps because of …

The orexinergic neurons of the lateral hypothalamus (LH) are critical for wakefulness
[McCarley RW (2007) Neurobiology of REM and NREM sleep. Sleep Med 8: 302–330] …

This review addresses three principal questions about adenosine and sleep–wake
regulation:(1) Is adenosine an endogenous sleep factor?(2) Are there specific brain regions …

There is considerable evidence to suggest that the activity of forebrain and mesopontine
cholinergic neurons is intimately involved in electroencephalographic arousal. Furthermore …

The majority of neurons in the magnocellular basal forebrain are wakefulness–active with
highest discharge activity during wakefulness and a marked reduction in activity just before …

Evidence suggests that adenosine (AD) is an endogenous sleep factor. The hypnogenic
action of AD is mediated through its inhibitory A1 and excitatory A2A receptors. Although AD …

The ventrolateral preoptic area of the hypothalamus (VLPO) contains a population of sleep-
active neurons and is hypothesized to be an important part of the somnogenic process …

1 The cholinergic system of the basal forebrain (BF) is hypothesized to play an important
role in behavioural and electrocortical arousal. Adenosine has been proposed as a sleep …