Background and objectives: The clinical use of non-steroidal anti-inflammatory drugs is
limited due to high incidence of adverse drug reactions. The pyrrole heterocycle is included …

Background: Persisting inflammatory stimuli cause chronic inflammation recognized as the
major factor contributing to the development of a number of diseases. One group of drugs …

The objective of our study was to evaluate the analgesic and anti-inflammatory activity, as
well as possible organ toxicity of 2-3-3-methyl-pentanoic acid (compound 3d), a newly …

The development of new COX-2 inhibitors with analgesic and anti-inflammatory efficacy as
well as minimal gastrointestinal, renal and cardiovascular toxicity, is of vital importance to …

Background: A new series of Celecoxib analogues were easily synthesized via reactions of
4-(2-(1-chloro-2-oxopropylidene) hydrazinyl) benzene sulfonamide (1) with active …

The pharmacological profile of celecoxib (CAS 169590-42-5, SC-58635), a specific
cyclooxygenase-2 (COX-2) inhibitor, was investigated. Celecoxib inhibited COX-2-mediated …

Twelve new compounds were designed as 5-aryl-1H-pyrrole analogs of celecoxib (CAS
169590-42-5) and were synthesized by Paal-Knorr cyclization in three series according to 1 …

Aim: To evaluate the analgesic effects of 2 celecoxib derivatives and their inhibitory effects
on cyclooxygenase (COX). Methods: Four antinociceptive assays were used: the acetic acid …

A number of 5-aryl-1-[4-(methylsulfonyl)-phenyl]-1H-pyrazoles and 4-(5-aryl-1H-pyrazol-1-
yl) benzenesulfonamides 3, 4, 5, 6, analogues of the COX-2 selective inhibitor celecoxib …

Pyrazolins 14a–l and pyrazoles 15a–l were designed as celecoxib analogs for the
evaluation of their in vitro COX-1/COX-2 inhibitory activity and the in vivo anti-inflammatory …