[HTML][HTML] Biological Screening of Novel Structural Analog of Celecoxib as Potential Anti-Inflammatory and Analgesic Agent
Background and objectives: The clinical use of non-steroidal anti-inflammatory drugs is
limited due to high incidence of adverse drug reactions. The pyrrole heterocycle is included …
limited due to high incidence of adverse drug reactions. The pyrrole heterocycle is included …
[PDF][PDF] In Vivo Evaluation of Anti-inflammatory Activity of 2-[3-Acetyl-5-(4-chloro-phenyl)-2-methyl-pyrrol-1-yl]-4-methylsulfanylbutyric Acid
H Zlatanova, S Vladimirova, I Kostadinov… - Folia Medica, 2018 - archive.sciendo.com
Background: Persisting inflammatory stimuli cause chronic inflammation recognized as the
major factor contributing to the development of a number of diseases. One group of drugs …
major factor contributing to the development of a number of diseases. One group of drugs …
[HTML][HTML] Novel N-Pyrrolylcarboxylic Acid Derivative as a Potential New Analgesic and Anti-Inflammatory Drug
H Zlatanova, S Vladimirova, I Kostadinov… - … Journal of Pain …, 2017 - oap-journals.info
The objective of our study was to evaluate the analgesic and anti-inflammatory activity, as
well as possible organ toxicity of 2-3-3-methyl-pentanoic acid (compound 3d), a newly …
well as possible organ toxicity of 2-3-3-methyl-pentanoic acid (compound 3d), a newly …
[HTML][HTML] Investigation of the anti-inflammatory and analgesic activities of promising pyrazole derivative
AA Bekhit, SN Nasralla, EJ El-Agroudy… - European Journal of …, 2022 - Elsevier
The development of new COX-2 inhibitors with analgesic and anti-inflammatory efficacy as
well as minimal gastrointestinal, renal and cardiovascular toxicity, is of vital importance to …
well as minimal gastrointestinal, renal and cardiovascular toxicity, is of vital importance to …
Design, Synthesis and In-vivo Anti-inflammatory Activity of New Celecoxib Analogues as NSAID
NA Abdel Hafez, KA Ali, AA Ibrahim… - Mini Reviews in …, 2018 - ingentaconnect.com
Background: A new series of Celecoxib analogues were easily synthesized via reactions of
4-(2-(1-chloro-2-oxopropylidene) hydrazinyl) benzene sulfonamide (1) with active …
4-(2-(1-chloro-2-oxopropylidene) hydrazinyl) benzene sulfonamide (1) with active …
Pharmacological profile of celecoxib, a specific cyclooxygenase-2 inhibitor
T Yoshino, A Kimoto, S Kobayashi… - …, 2005 - thieme-connect.com
The pharmacological profile of celecoxib (CAS 169590-42-5, SC-58635), a specific
cyclooxygenase-2 (COX-2) inhibitor, was investigated. Celecoxib inhibited COX-2-mediated …
cyclooxygenase-2 (COX-2) inhibitor, was investigated. Celecoxib inhibited COX-2-mediated …
Ligand-based design, synthesis and primary in vivo screening of pyrrole derivatives as potential tricyclic anti-inflammatory agents
A Bijev, D Yaneva, A Bocheva, G Stoev - Arzneimittelforschung, 2006 - thieme-connect.com
Twelve new compounds were designed as 5-aryl-1H-pyrrole analogs of celecoxib (CAS
169590-42-5) and were synthesized by Paal-Knorr cyclization in three series according to 1 …
169590-42-5) and were synthesized by Paal-Knorr cyclization in three series according to 1 …
Evaluation of 2 celecoxib derivatives: analgesic effect and selectivity to cyclooxygenase‐2/11
Z LU, X XIONG, B ZHANG, G LIN, Y SHI… - Acta …, 2005 - Wiley Online Library
Aim: To evaluate the analgesic effects of 2 celecoxib derivatives and their inhibitory effects
on cyclooxygenase (COX). Methods: Four antinociceptive assays were used: the acetic acid …
on cyclooxygenase (COX). Methods: Four antinociceptive assays were used: the acetic acid …
4-Substituted 1, 5-diarylpyrazole, analogues of celecoxib: synthesis and preliminary evaluation of biological properties
G Menozzi, L Merello, P Fossa, L Mosti, A Piana… - Il Farmaco, 2003 - Elsevier
A number of 5-aryl-1-[4-(methylsulfonyl)-phenyl]-1H-pyrazoles and 4-(5-aryl-1H-pyrazol-1-
yl) benzenesulfonamides 3, 4, 5, 6, analogues of the COX-2 selective inhibitor celecoxib …
yl) benzenesulfonamides 3, 4, 5, 6, analogues of the COX-2 selective inhibitor celecoxib …
1-(4-Methane (amino) sulfonylphenyl)-3-(4-substituted-phenyl)-5-(4-trifluoromethylphenyl)-1H-2-pyrazolines/pyrazoles as potential anti-inflammatory agents
Pyrazolins 14a–l and pyrazoles 15a–l were designed as celecoxib analogs for the
evaluation of their in vitro COX-1/COX-2 inhibitory activity and the in vivo anti-inflammatory …
evaluation of their in vitro COX-1/COX-2 inhibitory activity and the in vivo anti-inflammatory …