The structure and composition of bone varies with the tissue site and its origin (eg, lamellar
versus cortical, intramembranous versus endochondral) as well as with age, diet, and health …

Bone is composed of mineral and mineral ions, water and an organic matrix. Although the
relative proportions of mineral, water, and matrix molecules of bone vary among types …

Bone composes the largest proportion of the body's connective tissue mass. Unlike most
other connective tissue matrices, bone matrix is physiologically mineralized and is unique in …

Bone is a highly specialized form of connective tissue that is nature's provision for an
internal support system in all higher vertebrates. It is a complex living tissue in which the …

When the normal physiologic reaction to fracture does not occur, such as in fracture
nonunions or large-scale traumatic bone injury, surgical intervention is warranted. Autografts …

Publisher Summary The information and concepts described in this chapter form the basis
for understanding bone as a tissue and as an organ system. Bone is a mechanically …

The development, maintenance of healthy bone and regeneration of injured tissue in the
human body comprise a set of intricate and finely coordinated processes. However, an …

This chapter focuses on the extracellular matrix (ECM), which is synthesized primarily by
osteo‐blasts but also contains proteins adsorbed from the circulation. The preponderance of …

The tissue engineering of bone requires a fundamental understanding of physiological
homeostatic and regenerative principles. This chapter will focus on fundamental principles …

The logical assembly of tissue-engineered bone is ultimately directed by the clinical status of
the patient. The basic elements for tissue-engineered bone should include signaling …