The objective of this study was to examine the effects of long-term antihypertensive therapy
on blood pressure and vascular responses of resistance arteries during prolonged inhibition …

Objective: To examine the effects of hypertension induced by chronic inhibition of nitric oxide
synthase with NG-nitro-l-arginine methyl ester (l-NAME) on the structure of mesenteric …

Recent studies have indicated that acute inhibition of nitric oxide biosynthesis in the rat
promotes arterial hypertension and renal vasoconstriction. We evaluated the renal and …

The generation of nitric oxide by the vascular endothelium maintains a continuous
vasodilator tone that is essential for the regulation of blood flow and blood pressure. Nitric …

Objective: Since the effects of angiotensin II receptor antagonism on arterial function in nitric
oxide (NO)-deficient hypertension are unknown, we investigated the influence of losartan …

The responsiveness of isolated high-pressure (aorta, renal artery) and low-pressure vessels
(pulmonary artery) was compared during systemic hypertension induced by chronic …

To determine whether inhibition of generation of endothelium-derived relaxing factor or nitric
oxide (NO) resulted in elevated blood pressure and its effect on resistance arteries, rats …

The effects of the administration of either the angiotensin converting enzyme (ACE) inhibitor,
quinapril (10 mg/kg/day, orally), or the calcium antagonist, diltiazem (100 mg/kg/day, orally) …

BACKGROUND Patients with essential hypertension have abnormal endothelium-
dependent vasodilation. Because the endothelium exerts its action on the vascular smooth …

Background—Patients with essential hypertension have impaired endothelial NO activity,
but the mechanism underlying this abnormality is unknown. Methods and Results—To …