Advances in Chagas disease chemotherapy

PMM Guedes, JLR Fietto, M Lana… - Anti-Infective Agents in …, 2006 - ingentaconnect.com
Chagas disease is endemic from Mexico to Argentina, where it is estimated that 16 to 18
million people are infected with its causative agent, Trypanosoma cruzi, and 100 million …

Specific chemotherapy of Chagas disease: controversies and advances

JA Urbina, R Docampo - Trends in parasitology, 2003 - cell.com
Chagas disease, caused by Trypanosoma cruzi, is a major public health problem in Latin
America, where it constitutes one of the largest parasitic disease burdens. Specific treatment …

A decade of targets and patented drugs for chemotherapy of Chagas disease

VG Duschak - Recent patents on anti-infective drug discovery, 2011 - ingentaconnect.com
Chagas disease, a parasitic infection typically spread by triatomine bugs, affects millions of
people throughout Latin America. Current chemotherapy based on the nitroaromatic …

Targets and patented drugs for chemotherapy of Chagas disease in the last 15 years-period

VG Duschak - Recent patents on anti-infective drug discovery, 2016 - ingentaconnect.com
Background: The American trypanosomiasis, Chagas disease, is a parasitic infection
typically spread by triatomine vectors affecting millions of people all over Latin America …

[HTML][HTML] Experimental and clinical treatment of Chagas disease: a review

PAS Junior, I Molina, SMF Murta… - The American journal …, 2017 - ncbi.nlm.nih.gov
Chagas disease (CD) is caused by the protozoan parasite Trypanosoma cruzi that infects a
broad range of triatomines and mammalian species, including man. It afflicts 8 million …

Chagas disease: progress and new perspectives

F Sanchez-Sancho, NE Campillo… - Current Medicinal …, 2010 - ingentaconnect.com
Chagas disease, also known as American trypanosomiasis, is caused by infection with the
protozoan parasite Trypanosoma cruzi. The Pan American Health Organization (PAHO) …

[HTML][HTML] Recent developments in the control of Trypanosoma cruzi, the causative agent for Chagas' disease

JB Rodriguez, EG Gros - Current medicinal chemistry, 1995 - books.google.com
Chagas' disease is a terrible illness that affects million of people in Central and South
America. The causative agent for this disease is the hemoflagellate protozoan Trypanosoma …

Anti-T. cruzi agents: our experience in the evaluation of more than five hundred compounds

H Cerecetto, M Gonzalez - Mini reviews in medicinal chemistry, 2008 - ingentaconnect.com
Chagas' disease is the major endemic disease in South and Central America caused by a
trypanosomatid parasite (Trypanosoma cruzi). The current treatment relies on two old and …

[HTML][HTML] Chagas disease: Present status of pathogenic mechanisms and chemotherapy

JD Maya, M Orellana, J Ferreira, U Kemmerling… - Biological …, 2010 - SciELO Chile
There are approximately 7.8 million people in Latin America, including Chile, who suffer
from Chagas disease and another 28 million who are at risk of contracting it. Chagas is …

Stairway to heaven or hell? Perspectives and limitations of Chagas disease chemotherapy

K Salomao… - Current Topics in …, 2016 - ingentaconnect.com
In this review, we intend to provide a general view of the evolution of experimental studies in
the area of chemotherapy for Chagas disease. We can follow the process of drug …