Background Post-ischemic oxidative stress and inflammation play pivotal roles in the
pathogenesis of ischemic stroke and may represent therapeutic targets. Nobiletin (NOB) has …

Background: Nobiletin (NOB), isolated from Citrus nobilis, has been reported to inhibit
cerebral ischemia/reperfusion (I/R) induced cell apoptosis in the brain. The mechanisms and …

There is cumulative evidence that the serine-threonine kinase Akt and its downstream
nuclear transcription factor CREB are involved in neuronal survival and protection. The Akt …

Nobiletin, a citrus polymethoxylated flavone, is reported to possess various pharmacological
activities such as anticancer, anti-inflammation, and antioxidant effects. Recently, nobiletin …

Background Stroke is regarded as one of the main health concerns globally, presenting with
high mortality and morbidity rates. Cerebral ischemic damage and infarction are critically …

Increasing evidence indicates that nobiletin (NOB) is a promising neuroprotective agent.
Astrocyte activation plays a key role in neurodegenerative disorders. Thus, this study aims to …

Alzheimer's disease (AD) is presented as an age-related neurodegenerative disease with
multiple cognitive deficits and amyloid β (Aβ) accumulation is the most important involved …

Ethnopharmacological relevance Naoxintong (NXT), a renowned traditional Chinese
medicine in China, has been used for the treatment of acute and chronic cardio …

Objective This study aimed to explore the mechanism of Nobiletin attenuating Alzheimer's
disease (AD) by inhibiting neuroinflammation. Methods The expression of inflammatory …

Inflammatory damage plays a pivotal, mainly detrimental role in cerebral ischemic
pathogenesis and may represent a promising target for treatment. Naringenin (NG) has …