Anteroposterior polarity in the vertebrate limb is thought to be regulated in response to
signals derived from a specialized region of distal posterior mesenchyme, the zone of …

The gene encoding the secreted protein Sonic hedgehog (Shh) is expressed in the
polarizing region (or zone of polarizing activity), a small group of mesenchyme cells at the …

The zone of polarizing activity (ZPA) in the posterior limb bud produces Sonic Hedgehog
(Shh) protein, which plays a critical role in establishing distinct fates along the anterior …

In the vertebrate limb, the posteriorly located zone of polarizing activity (ZPA) regulates digit
identity through the morphogen Sonic Hedgehog (Shh). By genetically marking Shh …

Abstract Background: Sonic hedgehog (Shh), a vertebrate homolog of the Drosophila
segment polarity gene hedgehog (hh), has been implicated in patterning of the developing …

It has been proposed that digit identity in chick limb bud is specified in a dose-dependent
fashion by a long-range morphogen, produced by the polarising region. One candidate is …

Sonic hedgehog (Shh) is a key signal in establishing different digit fates along the anterior–
posterior axis of the vertebrate limb bud. Although the anterior digits appear to be specified …

The secreted protein encoded by the Sonic hedgehog (Shh) gene is localized to the
posterior margin of vertebrate limb buds and is thought to be a key signal in establishing …

The expression of Sonic hedgehog (Shh) in mouse limb buds is regulated by a long-range
enhancer 1 Mb upstream of the Shh promoter. We used 3D-FISH and chromosome …

Sonic hedgehog (Shh) expression in the developing limb is associated with the zone of
polarising activity (ZPA), and both are restricted to the posterior part of the limb bud. We …