Mesenchymal stromal cells are readily recoverable from lung tissue, but not the alveolar space, in healthy humans

KA Sinclair, ST Yerkovich, T Chen, JL McQualter… - Stem Cells, 2016 - academic.oup.com
Stromal support is critical for lung homeostasis and the maintenance of an effective
epithelial barrier. Despite this, previous studies have found a positive association between …

Lung-resident mesenchymal stromal cells are tissue-specific regulators of lung homeostasis

SN Sveiven, TM Nordgren - American Journal of …, 2020 - journals.physiology.org
Until recently, data supporting the tissue-resident status of mesenchymal stromal cells
(MSC) has been ambiguous since their discovery in the 1950–60s. These progenitor cells …

Primary mesenchymal stem cells in human transplanted lungs are CD90/CD105 perivascularly located tissue-resident cells

S Rolandsson, AA Sjöland, JC Brune… - BMJ open …, 2014 - bmjopenrespres.bmj.com
Background Mesenchymal stem cells (MSC) have not only been implicated in the
development of lung diseases, but they have also been proposed as a future cell-based …

The role of lung resident mesenchymal stromal cells in the pathogenesis and repair of chronic lung disease

DF Doherty, L Roets, AD Krasnodembskaya - Stem Cells, 2023 - academic.oup.com
Mesenchymal stromal/stem cells are multipotent adult cells that can be extracted from
numerous tissues, including the lungs. Lung-resident MSCs (LR-MSCs) are localized to …

Abnormalities in reparative function of lung-derived mesenchymal stromal cells in emphysema

DMLW Kruk, M Wisman, HG Bruin… - … of Physiology-Lung …, 2021 - journals.physiology.org
Mesenchymal stromal cells (MSCs) may provide crucial support in the regeneration of
destructed alveolar tissue (emphysema) in chronic obstructive pulmonary disease (COPD) …

Comparison of epithelial differentiation and immune regulatory properties of mesenchymal stromal cells derived from human lung and bone marrow

M Ricciardi, G Malpeli, F Bifari, G Bassi, L Pacelli… - PLoS …, 2012 - journals.plos.org
Mesenchymal stromal cells (MSCs) reside in many organs including lung, as shown by their
isolation from fetal lung tissues, bronchial stromal compartment, bronchial-alveolar lavage …

Persistency of mesenchymal stromal/stem cells in lungs

E Ferrini, FF Stellari, V Franceschi, F Macchi… - Frontiers in cell and …, 2021 - frontiersin.org
Mesenchymal stromal/stem cells (MSCs) are a fibroblast-like cell population with high
regenerative potential that can be isolated from many different tissues. Several data suggest …

Epithelial cell differentiation of human mesenchymal stromal cells in decellularized lung scaffolds

JJ Mendez, M Ghaedi, D Steinbacher… - … Engineering Part A, 2014 - liebertpub.com
Identification of appropriate donor cell types is important for lung cell therapy and for lung
regeneration. Previous studies have indicated that mesenchymal stromal cells derived from …

Mesenchymal stem cells in chronic lung disease: culprit or savior?

M Pierro, B Thébaud - American Journal of Physiology …, 2010 - journals.physiology.org
CHRONIC LUNG DISEASES such as chronic obstructive pulmonary disease (COPD) and
emphysema are anticipated to become the third most common cause of death by 2030 (30) …

Lung-derived mesenchymal stromal cell post-transplantation survival, persistence, paracrine expression, and repair of elastase-injured lung

AM Hoffman, JA Paxson, MR Mazan… - Stem cells and …, 2011 - liebertpub.com
While multipotent mesenchymal stromal cells have been recently isolated from adult lung (L-
MSCs), there is very limited data on their biological properties and therapeutic potential in …