Despite continuous deployment of new treatment strategies and agents over many decades,
most disseminated cancers remain fatal. Cancer cells, through their access to the vast …

Despite the continuous deployment of new treatment strategies and agents over many
decades, most disseminated cancers remain fatal. Cancer cells, through their access to the …

Acquired drug resistance is a major limitation for the successful treatment of cancer.
Resistance can emerge due to a variety of reasons including host environmental factors as …

Therapeutic resistance continues to be an indominable foe in our ambition for curative
cancer treatment. Recent insights into the molecular determinants of acquired treatment …

Drug resistance is a serious impediment to the treatment of cancer. However, the
mechanisms involved remain poorly understood. While it is widely held that the …

Many effective drugs for metastatic and/or advanced-stage cancers have been developed
over the past decade, although the evolution of resistance remains the major barrier to …

Therapeutic resistance is a key roadblock to effective cancer treatment and can occur
through various mechanisms. A recent study characterized a previously unknown, reversible …

Background The development of resistance is a problem shared by both classical
chemotherapy and targeted therapy. Patients may respond well at first, but relapse is …

As well as undergoing genetic evolution, cancer cells can alter their epigenetic state to
adapt and resist treatment. This non-genetic evolution is emerging as a major component of …

The capacity of cancer to adapt to treatment and evolve is a major limitation for targeted
therapies. While the role of new acquired mutations is well-established, recent findings …