Design, Synthesis, Biological Evaluation, and Molecular Modeling of Coumarin–P iperazine Derivatives as Acetylcholinesterase Inhibitors
RP Modh, SP Kumar, YT Jasrai… - Archiv der …, 2013 - Wiley Online Library
Acetylcholinesterase (AChE) is an important drug target for the treatment of Alzheimer's
disease. A novel series of coumarin–piperazine derivatives were synthesized and their …
disease. A novel series of coumarin–piperazine derivatives were synthesized and their …
Design and synthesis of novel coumarin derivatives as potential acetylcholinesterase inhibitors for Alzheimer's disease
Twenty novel 7-benzyloxycoumarin based compounds were synthesized with a variety of
bioactive chemical fragments. The synthesized compounds showed remarkable …
bioactive chemical fragments. The synthesized compounds showed remarkable …
Synthesis of 2‐(2‐oxo‐2H‐chromen‐4‐yl)acetamides as potent acetylcholinesterase inhibitors and molecular insights into binding interactions
J Kara, P Suwanhom, C Wattanapiromsakul… - Archiv der …, 2019 - Wiley Online Library
Sixteen novel coumarin‐based compounds are reported as potent acetylcholinesterase
(AChE) inhibitors. The most active compound in this series, 5a (IC50 0.04±0.01 µM) …
(AChE) inhibitors. The most active compound in this series, 5a (IC50 0.04±0.01 µM) …
Synthesis and evaluation of 4-substituted coumarins as novel acetylcholinesterase inhibitors
A series of 4-hydroxycoumarin derivatives were designed and synthesized as new
acetylcholinesterase (AChE) inhibitors which could be considered for Alzheimer's disease …
acetylcholinesterase (AChE) inhibitors which could be considered for Alzheimer's disease …
Synthesis, biological evaluation and in silico study of 4-(benzo [d] thiazole-2-yl) phenols based on 4-hydroxy coumarin as acetylcholinesterase inhibitors
BBF Mirjalili, SA Fazeli Attar, F Shiri - Scientific Reports, 2024 - nature.com
Alzheimer's disease, characterized by cognitive decline and memory loss, is associated with
decreased acetylcholine levels due to acetylcholinesterase (AChE) activity. Compounds …
decreased acetylcholine levels due to acetylcholinesterase (AChE) activity. Compounds …
Coumarin derivatives as potential inhibitors of acetylcholinesterase: Synthesis, molecular docking and biological studies
S Singla, P Piplani - Bioorganic & Medicinal Chemistry, 2016 - Elsevier
A series of novel hybrids has been synthesized by linking coumarin moiety through an
appropriate spacer to various substituted heterocyclic amines and evaluated as dual binding …
appropriate spacer to various substituted heterocyclic amines and evaluated as dual binding …
Use of ligand-based pharmacophore modeling and docking approach to find novel acetylcholinesterase inhibitors for treating Alzheimer's
Alzheimer's disease is a neurological disorder in which the patient suffers from memory loss
and impaired cognitive abilities. Though the main cause of the disease is not yet known …
and impaired cognitive abilities. Though the main cause of the disease is not yet known …
Novel chalcone derivatives of ursolic acid as acetylcholinesterase inhibitors: Synthesis, characterization, biological activity, ADME prediction, molecular docking and …
Acetylcholinesterase (AChE) is a critical target in the prevention of Alzheimer's Disease (AD)
progression. With the goal of developing potential acetylcholinesterase inhibitors, a new …
progression. With the goal of developing potential acetylcholinesterase inhibitors, a new …
Cholinesterase inhibition activity and docking simulation study of coumarin mannich base derivatives
Inhibition of acetylcholinesterase and butyrylcholinesterase (AChE and BuChE) as two
major forms of cholinesterases (ChEs) is considered as the common approach for the …
major forms of cholinesterases (ChEs) is considered as the common approach for the …
Synthesis, biological evaluation, and molecular dynamics of novel coumarin based phosphorothioates as cholinesterase inhibitors
M El-Hussieny, MF ElMansy, EF Ewies… - Journal of Molecular …, 2023 - Elsevier
Inhibition of acetylcholinesterase has been validated as an effective target for treatment of
Alzheimer's disease by increasing the levels of acetylcholine and improving the …
Alzheimer's disease by increasing the levels of acetylcholine and improving the …
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