Genetic deletion of IL-17A reduces cigarette smoke-induced inflammation and alveolar type II cell apoptosis

Y Chang, L Al-Alwan, S Audusseau… - … of Physiology-Lung …, 2014 - journals.physiology.org
Chronic obstructive pulmonary disease (COPD) is an inflammatory disorder marked by
relative resistance to steroids. Inflammation and apoptosis have been suggested to be …

Il-17A contributes to maintenance of pulmonary homeostasis in a murine model of cigarette smoke-induced emphysema

M Voss, L Wolf, A Kamyschnikow… - … of Physiology-Lung …, 2015 - journals.physiology.org
Smoking is the main risk factor for the development of the chronic obstructive pulmonary
disease (COPD) in Western countries. Recent studies suggest that IL-17A and Th17 cells …

Innate cellular sources of interleukin-17A regulate macrophage accumulation in cigarette-smoke-induced lung inflammation in mice

S Bozinovski, HJ Seow, SPJ Chan, D Anthony… - Clinical …, 2015 - portlandpress.com
Cigarette smoke (CS) is the major cause of chronic obstructive pulmonary disease (COPD).
Interleukin-17A (IL-17A) is a pivotal cytokine that regulates lung immunity and inflammation …

[HTML][HTML] Upregulation of IL-17A/F from human lung tissue explants with cigarette smoke exposure: implications for COPD

Y Chang, L Al-Alwan, S Alshakfa, S Audusseau… - Respiratory …, 2014 - Springer
Background Chronic obstructive pulmonary disease (COPD) is an inflammatory disorder
marked by relative resistance to steroids. The IL-17 superfamily, which mediates cross-talk …

Increased interleukin (IL)-8 and decreased IL-17 production in chronic obstructive pulmonary disease (COPD) provoked by cigarette smoke

X Zhang, H Zheng, H Zhang, W Ma, F Wang, C Liu… - Cytokine, 2011 - Elsevier
Recently, involvement of IL-17 in development of COPD has been noticed. Unlike IL-8, the
role of IL-17 in COPD remains controversial. In order to further understand mechanisms in …

[HTML][HTML] Cigarette smoke extract enhances IL-17A-induced IL-8 production via up-regulation of IL-17R in human bronchial epithelial cells

KH Lee, CH Lee, J Woo, J Jeong, AH Jang, CG Yoo - Molecules and cells, 2018 - Elsevier
Interleukin-17A (IL-17A) is a pro-inflammatory cytokine mainly derived from T helper 17 cells
and is known to be involved in the pathogenesis of chronic obstructive pulmonary disease …

IL-18 is induced and IL-18 receptor α plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation

MJ Kang, RJ Homer, A Gallo, CG Lee… - The Journal of …, 2007 - journals.aai.org
Th1 inflammation and remodeling characterized by local tissue destruction coexist in
pulmonary emphysema and other diseases. To test the hypothesis that IL-18 plays an …

Cigarette smoke affects IL-17A, IL-17F and IL-17 receptor expression in the lung tissue: Ex vivo and in vitro studies

AM Montalbano, L Riccobono, L Siena, G Chiappara… - Cytokine, 2015 - Elsevier
Cigarette smoke is a risk factor for Chronic Obstructive Pulmonary Disease (COPD). Th-17
cytokines are involved in the pathogenesis of COPD. We aimed to evaluate the role of …

IL-17A is elevated in end-stage chronic obstructive pulmonary disease and contributes to cigarette smoke–induced lymphoid neogenesis

AB Roos, C Sandén, M Mori, L Bjermer… - American journal of …, 2015 - atsjournals.org
Rationale: End-stage chronic obstructive pulmonary disease (COPD) is associated with an
accumulation of pulmonary lymphoid follicles. IL-17A is implicated in COPD and pulmonary …

Interleukin-10 modulates pulmonary neutrophilic inflammation induced by cigarette smoke exposure

M Higaki, H Wada, S Mikura, T Yasutake… - Experimental lung …, 2015 - Taylor & Francis
ABSTRACT Aim of the Study: Interleukin (IL)-10 is an anti-inflammatory cytokine, but its role
in cigarette smoke (CS)-induced inflammation and chronic obstructive pulmonary disease …