Protein traffic is necessary to maintain homeostasis in all eukaryotic organisms. All newly
synthesized secretory proteins destined to the secretory and endolysosmal systems are …

Vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex constitutes the
initial step in protein secretion. COPII‐coated vesicles mediate the export of newly …

▪ Abstract The endoplasmic reticulum (ER) and the Golgi comprise the first two steps in
protein secretion. Vesicular carriers mediate a continuous flux of proteins and lipids between …

Forward and retrograde trafficking of secretory proteins between the endoplasmic reticulum
and the Golgi apparatus is driven by two biochemically distinct vesicle coats, COPI and …

COPII and COPI mediate the formation of membrane vesicles translocating in opposite
directions within the secretory pathway. Live-cell and electron microscopy revealed a novel …

Protein transport from the endoplasmic reticulum (ER) to the Golgi apparatus is mediated by
coat complex II (COPII) vesicles. It has been believed that COPII vesicles containing cargo …

Vesicle trafficking from the endoplasmic reticulum (ER) is a vital cellular process in all
eukaryotes responsible for moving secretory cargoes from the ER to the Golgi apparatus. To …

Coat protein complex I (COPI) and COPII are required for bidirectional membrane trafficking
between the endoplasmic reticulum (ER) and the Golgi. While these core coat machineries …

What is the first membrane fusion step in the secretory pathway? In mammals, transport
vesicles coated with coat complex (COP) II deliver secretory cargo to vesicular tubular …

The realization that the meticulous organization of cellular organelles is not required for the
reconstitution of select intracellular traffic steps has revolutionized cell biology. It transformed …