Sickle cell anemia is an inherited genetic disorder arising from a point mutation in the $\beta
$-globin gene that leads to the replacement of Glu by Val at the sixth position of the $\beta …

Sickle cell anemia is a genetic blood disorder arising from a point mutation in the b-globin
gene that leads to the replacement of glutamic acid residue by valine at the sixth position of …

Five (2, 2-dimethylchroman-6-yl) alkanoic acids were synthesized and tested for antigelling
activities. It was envisioned that these agents might bind via hydrophobic bonding to …

The hallmark of sickle cell disease is the polymerization of sickle haemoglobin due to a point
mutation in the β‐globin gene (HBB). Under low oxygen saturation, sickle haemoglobin …

Publisher Summary This chapter discusses the sickle cell anemia along with its treatment
with anti-sickling agents. The lack of treatment for sickle cell anemia prevails even though …

In the past two decades, chemical modifiers of hemoglobin have contributed to our
understanding of the molecular disease-sickle cell anemia. These modifiers are of two types …

Recent biochemical and biophysical studies of sickle cell hemoglobin have provided
valuable insight into the molecular basis of the sickling phenomenon in sickle cell disease. A …

Chemical modification of sickle hemoglobin (Hb S) to form stable high affinity Schiff-base
adducts has been an attractive approach towards finding a potential therapeutic option for …

Compounds that bind to sickle hemoglobin (Hb S) producing an allosteric shift to the high‐
affinity Hb S that does not polymerize are being developed to treat sickle cell anemia (SCA) …

Sickle cell anemia is a genetic disease in which the erythrocytes have lost their diskoid
shape (1) and their pliability because of the intracellular aggregates of hemoglobin S that …