Macrophages are key innate immune cells in the tumor microenvironment that regulate
primary tumor growth, vascularization, metastatic spread and response to therapies …

Colon cancer poses a great threat to human health. Currently, there is no effective treatment
for colon cancer due to its complex causative factors. Immunotherapy has now become a …

Objectives The exhausted CD8+ T (Tex) cells are a unique cell population of activated T
cells that emerges in response to persistent viral infection or tumor antigens. Tex cells …

Background Gastric cancer (GC) is the fifth most common cancer and the second leading
cause of cancer-related deaths worldwide. Due to the lack of specific markers, the early …

Background Myocardial infarction (MI) is one of the most severe manifestations of coronary
artery disease (CAD) and the leading cause of death from non-infectious diseases …

The tumor microenvironment (TME) plays an important role in the pathogenesis of many
cancers. We aimed to screen the TME-related hub genes of colorectal adenoma (CRAD) …

Background. Coronary heart disease (CHD) is an ischemic heart disease involving a variety
of immune factors. This study was aimed at investigating unique immune and m6A patterns …

Coronary artery disease (CAD) is a major cause of death worldwide. The role of CD8+ T
cells in CAD is unknown. Recent studies suggest a breakdown of tolerance in …

Background Atherosclerosis is a major contributor to morbidity and mortality worldwide.
Although several molecular markers associated with atherosclerosis have been developed …

Background: CD8+ T cells, a critical component of the tumor immune microenvironment,
have become a key target of cancer immunotherapy. Considering the deficiency of robust …