Erythropoietin protects PC12 cells from β-amyloid25–35-induced apoptosis via PI3K/Akt signaling pathway

R Ma, N Xiong, C Huang, Q Tang, B Hu, J Xiang… - Neuropharmacology, 2009 - Elsevier
Although the etiology of Alzheimer's disease (AD) is not fully understood, multiple lines of
evidence suggests the importance of amyloid-β (Aβ) in the initiation/progression of the …

[HTML][HTML] Erythropoietin prevents PC12 cells from beta-amyloid-induced apoptosis via PI3K⁄ Akt pathway

S Zhi-Kun, Y Hong-Qi, W Zhi-Quan, P Jing… - Translational …, 2012 - Springer
Background Several studies indicated that Erythropoietin (Epo) may provide remarkable
neuroprotection in some neurological diseases. It also showed the significant decrease of …

JAK2/STAT5/Bcl‐xL signalling is essential for erythropoietin‐mediated protection against apoptosis induced in PC12 cells by the amyloid β−peptide Aβ25–35

R Ma, J Hu, C Huang, M Wang… - British journal of …, 2014 - Wiley Online Library
Background and Purpose Erythropoietin (EPO) exerts neuroprotective actions in the CNS,
including protection against apoptosis induced by the amyloid β− peptide Aβ 25–35 …

Protective effect of erythropoietin on β-amyloid-induced PC12 cell death through antioxidant mechanisms

G Li, R Ma, C Huang, Q Tang, Q Fu, H Liu, B Hu… - Neuroscience …, 2008 - Elsevier
Erythropoietin (EPO), a haematopoietic growth factor has been reported to display
neuroprotective properties in different animal models. In the present study, we investigated …

Erythropoietin attenuates Alzheimer-like memory impairments and pathological changes induced by amyloid β42 in mice

Y Li, G Yang, L Jin, H Yang, J Chen, G Chai, L Wang - Brain research, 2015 - Elsevier
Amyloid beta (Aβ) is a key molecule in the neurodegenerative progression of Alzheimer׳ s
disease (AD). It is critical to develop a treatment that can arrest the Aβ-induced pathologic …

Protective effect of erythropoietin against ketamine-induced apoptosis in cultured rat cortical neurons: involvement of PI3K/Akt and GSK-3 beta pathway

Y Shang, Y Wu, S Yao, X Wang, D Feng, W Yang - Apoptosis, 2007 - Springer
Erythropoietin (EPO) prevents neuronal cell death through the activation of cell survival
signals and the inhibition of apoptotic signals in models of neurodegenerative diseases …

Erythropoietin protects neurons from apoptosis via activating PI3K/AKT and inhibiting Erk1/2 signaling pathway

W Si, J Wang, M Li, H Qu, R Gu, R Liu, L Wang, S Li… - 3 Biotech, 2019 - Springer
The aim of this study was to explore the neuroprotective effect and the underlying
mechanism of erythropoietin (EPO) on the cortical neuronal cells insulted with oxygen and …

Erythropoietin exerts cell protective effect by activating PI3K/Akt and MAPK pathways in C6 Cells

MS Kwon, MH Kim, SH Kim, KD Park, SH Yoo… - Neurological …, 2014 - Taylor & Francis
Even though erythropoietin (EPO) is a neurotropic cytokine that is recognized widely for its
role in the development, maintenance, protection, and repair of the nervous system, there …

Erythropoietin requires NF-κB and its nuclear translocation to prevent early and late apoptotic neuronal injury during β-amyloid toxicity

ZZ Chong, F Li, K Maiese - Current neurovascular research, 2005 - ingentaconnect.com
No longer considered exclusive for the function of the hematopoietic system, erythropoietin
(EPO) is now considered as a viable agent to address central nervous system injury in a …

Pycnogenol® protects neurons from amyloid-β peptide-induced apoptosis

QL Peng, AR Buz'Zard, BHS Lau - Molecular Brain Research, 2002 - Elsevier
Neuronal apoptosis is one of the pathological features of Alzheimer's disease (AD).
Morphological pathology reveals that neuronal apoptosis is associated with senile plaques …