Objectives Voriconazole exhibits non-linear pharmacokinetics in adults and is said to be
mainly metabolized by CYP2C19 and CYP3A4 to voriconazole-N-oxide. The aim of this …

Voriconazole pharmacokinetics shows a large inter-and intrapatient variability. Inflammation
is associated with changes in the expression of CYP isoenzymes. Here, we evaluated the …

In this study, the safety, tolerability, and pharmacokinetics of intravenous (iv)-to oral-dose
regimens of voriconazole were evaluated with a group of 42 healthy men, 41 of whom …

An important element in antimicrobial stewardship programmes is early switch from
intravenous (iv) to oral antimicrobial treatment, especially for highly bioavailable drugs. The …

ABSTRACT A new selective high-performance liquid chromatography (HPLC) method with
UV detection for the determination of the investigational triazole voriconazole in human …

Background Voriconazole therapeutic drug monitoring (TDM) is increasingly used in clinical
practice. However, the utility of voriconazole TDM to guide therapy remains uncertain and …

Objectives Voriconazole exhibits highly variable, non-linear pharmacokinetics and is
associated with a narrow therapeutic range. This study aimed to investigate the population …

Background Therapeutic drug monitoring (TDM) is recommended to guide voriconazole
therapy. Objectives To determine compliance of hospital-based voriconazole dosing and …

Voriconazole, a second-generation triazole frequently used for the prophylaxis and
treatment of invasive fungal infections, undergoes complex metabolism mainly involving …

The objective of this study was to investigate the safety, tolembility, and pharmacokinetics of
oral voriconazole in subjects at high risk of developing fungal infections. This was a …