BACKGROUND: New evidence suggests that different β2-adrenergic receptor (β2AR)
polymorphisms may influence asthma control in patients receiving long-acting β2-agonists …

Background β 2-adrenergic receptor agonists are the mainstay of treatment for severe
asthma exacerbations, one of the most common causes of critical illness in children …

BACKGROUND: On-demand inhaled albuterol is commonly prescribed worldwide. We have
shown that the Arg16 allele of the adrenergic β2-receptor agonist gene (ADRB2) …

Rationale: Several studies suggest that patients with asthma who are homozygous for
arginine at the 16th position of the β2-adrenergic receptor may not benefit from short-acting …

BACKGROUND Polymorphisms of the β2 adrenoceptor influence receptor function in vitro
and asthma phenotypes in vivo. However, their importance in determining responses to …

Background Alterations of B2 adrenergic receptor (β 2 AR) can modulate the severity of
asthma and the response to treatment. Therefore, we aimed to evaluate β 2 AR gene …

Background Several studies have suggested that after regular use of short acting β2‐
agonists the bronchodilator effect of the drug may decline and this condition would be …

Methods Subjects (≥ 12 years) were randomized in equal numbers (∼ 90 per group) by
genotype (Arg/Arg, Gly/Gly and Arg/Gly) to FP/salmeterol 100/50 mcg (FSC) or salmeterol 50 …

The aim of this study was to determine the influence of single nucleotide polymorphisms in
the β2-adrenoceptor gene, on the response to inhaled β2-agonists in children with acute …

Methods Subjects were randomized by Arg16Gly genotype to fluticasone
propionate/salmeterol 100/50 mcg (FSC) or salmeterol 50 mcg BID for 16-weeks, followed …