The hijacking of HBV by small extracellular vesicles inhibits M1 macrophages to facilitate immune evasion

Z Zhang, J Liu, L Yu, R Zeng, W Pan - Scientific Reports, 2024 - nature.com
Small extracellular vesicles (sEVs) have the ability to transfer genetic material between cells,
but their role in mediating HBV infection and regulating M1 macrophages to promote …

Critical contributions of protein cargos to the functions of macrophage-derived extracellular vesicles

B Liu, PL Nguyen, H Yu, X Li, H Wang, J Price… - Journal of …, 2023 - Springer
Background Macrophages are highly plastic innate immune cells that play key roles in host
defense, tissue repair, and homeostasis maintenance. In response to divergent stimuli …

Immune cell-derived extracellular vesicles–functions and therapeutic applications

RE Veerman, GG Akpinar, M Eldh… - Trends in molecular …, 2019 - cell.com
Extracellular vesicles (EVs) are nano-sized vesicles with the capacity to transfer nucleic
acids, proteins, and lipids, and are released by all cells. EV is an umbrella term for …

The role and impact of extracellular vesicles in the modulation and delivery of cytokines during autoimmunity

MT Hussain, AJ Iqbal, LV Norling - International journal of molecular …, 2020 - mdpi.com
Cytokines and extracellular vesicles are two methods of initiating and maintaining cellular
crosstalk. The role of cytokines in the initiation, progression, and resolution of inflammation …

Modulating cytokine production via select packaging and secretion from extracellular vesicles

BJ Barnes, CC Somerville - Frontiers in Immunology, 2020 - frontiersin.org
Cytokines are soluble factors that play vital roles in systemic function due to their ability to
initiate and mediate cell-to-cell communication. Another important mechanism of …

[HTML][HTML] Monocyte exosomes induce adhesion molecules and cytokines via activation of NF-κB in endothelial cells

N Tang, B Sun, A Gupta, H Rempel… - The FASEB Journal, 2016 - ncbi.nlm.nih.gov
HIV-infected individuals have activated monocytes with an IFNα phenotype and elevated
levels of circulating LPS. These individuals also have a risk of premature cardiovascular …

The roles of extracellular vesicles in the immune system

EI Buzas - Nature Reviews Immunology, 2023 - nature.com
The twenty-first century has witnessed major developments in the field of extracellular
vesicle (EV) research, including significant steps towards defining standard criteria for the …

Extracellular vesicles derived from GMSCs stimulated with TNF-α and IFN-α promote M2 macrophage polarization via enhanced CD73 and CD5L expression

Y Watanabe, T Fukuda, C Hayashi, Y Nakao… - Scientific reports, 2022 - nature.com
Immunoregulatory properties of mesenchymal stem cell (MSC)-derived extracellular vesicles
(EVs) are promising. Gingival tissue-derived MSCs (GMSCs) have unique …

Extracellular vesicles in transplantation

N Sailliet, M Ullah, A Dupuy, AKA Silva… - Frontiers in …, 2022 - frontiersin.org
Extracellular vesicles (EVs) have been extensively studied in the last two decades. It is now
well documented that they can actively participate in the activation or regulation of immune …

Immune cells-derived exosomes function as a double-edged sword: role in disease progression and their therapeutic applications

A Hazrati, S Soudi, K Malekpour, M Mahmoudi… - Biomarker …, 2022 - Springer
Exosomes, ranging in size from 30 to 150 nm as identified initially via electron microscopy in
1946, are one of the extracellular vesicles (EVs) produced by many cells and have been the …