M1 But Not M0 Extracellular Vesicles Induce Polarization of RAW264.7 Macrophages Via the TLR4-NFκB Pathway In Vitro

Y Shi, P Luo, W Wang, K Horst, F Bläsius, B Relja, D Xu… - Inflammation, 2020 - Springer
In response to different stimuli (eg, infections), naive macrophages polarize into M1
macrophages, which have the potential to secrete numerous pro-inflammatory cytokines and …

Immunoregulatory molecule expression on extracellular microvesicles in people living with HIV

D Neyrinck-Leglantier, M Tamagne… - Frontiers in …, 2024 - frontiersin.org
Introduction People living with HIV (PLWH) now benefit from combined antiviral treatments
that durably control viral replication. These antiretroviral treatments decrease mortality and …

Extracellular vesicles participate in macrophage-involved immune responses under liver diseases

J Shao, S Li, Y Liu, M Zheng - Life sciences, 2020 - Elsevier
bstract The liver serves as a central participant in immune system owing to its particular
blood supply and large amounts of immune cells, in which macrophages play a significant …

The immuno-modulation effect of macrophage-derived extracellular vesicles in chronic inflammatory diseases

Y Xing, X Sun, Y Dou, M Wang, Y Zhao… - Frontiers in …, 2021 - frontiersin.org
As natural nanocarriers and intercellular messengers, extracellular vesicles (EVs) control
communication among cells. Under physiological and pathological conditions, EVs deliver …

Therapeutic potential of extracellular vesicles

AM Merino, MJ Hoogduijn, FE Borras… - Frontiers in …, 2014 - frontiersin.org
Extracellular vesicles (EV) have emerged as important mediators of intercellular
communication. By their origin, we can find vesicles derived from plasma membrane such as …

Regulatory role of immune cell-derived extracellular vesicles in cancer: the message is in the envelope

C Li, H Donninger, J Eaton, K Yaddanapudi - Frontiers in Immunology, 2020 - frontiersin.org
Extracellular vesicles (EVs) are a heterogenous group of membrane-surrounded structures.
Besides serving as a harbor for the unwanted material exocytosed by cells, EVs play a …

Extracellular Vesicles and Their Use as Vehicles of Immunogens

C Chiozzini, B Ridolfi, M Federico - Extracellular Vesicles in Diagnosis …, 2022 - Springer
Healthy cells constitutively release lipid bilayered vesicles of different sizes and recognizing
different biogenesis, collectively referred to as extracellular vesicles (EVs). EVs can be …

Label-free proteomic analysis of exosomes secreted from THP-1-derived macrophages treated with IFN-α identifies antiviral proteins enriched in exosomes

Z Yao, X Jia, DA Megger, J Chen, Y Liu… - Journal of proteome …, 2018 - ACS Publications
Exosomes are extracellular vesicles that function in intercellular communication. We have
previously reported that exosomes play an important role in the transmission of antiviral …

New insights into immune cell-derived extracellular vesicles in multiple sclerosis

M Blonda, A Amoruso, T Martino, C Avolio - Frontiers in neurology, 2018 - frontiersin.org
Extracellular vesicles (EVs) are small vesicles including microvesicles and exosomes which
differ in their distinct size, density, biogenesis, and content. Until recently, EVs were …

Molecular characterization of msc-derived extracellular vesicles and correlation with their immunomodulatory potential

A Adamo, J Brandi, R Carusone, S Caligola, D Cecconi… - Cytotherapy, 2018 - iris.univr.it
Mesenchymal stromal cells (MSCs) are adult, multipotent stem cells of mesodermal origin. In
addition to their stem cell properties, MSCs possess broad immunosuppressive functions …