Objectives The high levels of morbidity and mortality associated with cancer can be
attributed to two main processes; the tumour's ability to rapidly proliferate and the process of …

The tumour microenvironment and tumour angiogenesis play a critical role in the
development and therapy of many cancers, but in vitro models reflecting these …

Tumor-associated vessels constitution is the result of angiogenesis, the hallmark of cancer
essential for tumor to develop in dimension and to spread throughout the organism. Tumor …

Communication between tumor cells and stromal cells is crucial to tumor development and
progression. Fibroblasts and macrophages are the most common stromal cells in the tumor …

Coculture assays allow the investigation of the role of endothelial cell and mural cell
interactions in small vessel development and function. Different setups for coculture can be …

Angiogenesis is an essential aspect of tumour growth and metastasis. Solid tumours cannot
grow beyond 2-3 mm in diameter without inducing the formation of new blood vessels to …

Angiogenesis is a critical process required for tumor progression. Newly formed blood
vessels provide nutrition and oxygen to the tumor contributing to its growth and …

The establishment of a vascular network within tumours is a key step in the progression
towards an aggressive, metastatic state, with poor prognosis. We have developed a novel in …

Angiogenesis marks the transformation of a benign local tumor into a life‐threatening
disease. Many in vitro assays are available on two‐dimensional (2D) platforms, however …

Emerging evidence shows that endothelial cells are not only the building blocks of vascular
networks that enable oxygen and nutrient delivery throughout a tissue but also serve as a …