Over the past decade or so, there has been a large number of modeling approaches aimed
at elucidating the most important mechanisms affecting the formation of new capillaries from …

It is generally accepted that angiogenesis plays a major role in tumor growth and numerous
targeting agents directed against angiogenesis pathways have been developed and …

Biological evolution is economical and successful fundamental processes are frequently
recapitulated. There are remarkable similarities in the molecular mechanisms which enable …

It is now common knowledge that for a solid tumour to become life-threatening clinically, an
adequate blood supply to the neoplasm has to be established. Although neovascularisation …

Bone marrow-derived endothelial precursor cells contribute to tumor neovascularization.
However, it is unclear when during progressive tumor growth circulating precursors are …

Genetic and pathophysiologic criteria prearrange the uncontrolled growth of neoplastic cells
that in turn initiates new vessel formation, which is prerequisite for further tumor growth and …

Angiogenesis is a term that describes the formation of new blood and lymphatic vessels from
a pre-existing vasculature. This allows tumour cells to acquire sustenance in the form of …

Tumours display considerable variation in the patterning and properties of angiogenic blood
vessels, as well as in their responses to anti-angiogenic therapy. Angiogenic programming …

A deeper understanding of the mechanisms of tumor cell extravasation is essential in
creating therapies that target this crucial step in cancer metastasis. Here, we use a …

Tumor angiogenesis is a hallmark of cancer that has been identified as a critical component
of cancer progression, facilitating rapid tumor growth and metastasis. Anti-angiogenic …