Genome-wide association studies (GWASs) identified hundreds of signals associated with
type 2 diabetes (T2D). To gain insight into their underlying molecular mechanisms, we have …

Genome-wide association studies (GWAS) have identified> 100 independent SNPs that
modulate the risk of type 2 diabetes (T2D) and related traits. However, the pathogenic …

Human genetic studies have emphasised the dominant contribution of pancreatic islet
dysfunction to development of Type 2 Diabetes (T2D). However, limited annotation of the …

Abstract Objective Type 2 diabetes (T2D) is a complex disease characterized by pancreatic
islet dysfunction, insulin resistance, and disruption of blood glucose levels. Genome-wide …

Type 2 diabetes mellitus (T2DM) is an increasingly prevalent multifactorial disease that has
both genetic and environmental risk factors, resulting in impaired glucose homeostasis …

Genetic variation can modulate gene expression, and thereby phenotypic variation and
susceptibility to complex diseases such as type 2 diabetes (T2D). Here we harnessed the …

Identifying cis-regulatory elements is important to understanding how human pancreatic
islets modulate gene expression in physiologic or pathophysiologic (eg, diabetic) conditions …

Genome-wide association studies (GWAS) have identified over 400 signals robustly
associated with risk for type 2 diabetes (T2D). At the vast majority of these loci, the lead …

Pancreatic islet dysfunction and beta cell failure are hallmarks of type 2 diabetes mellitus
(T2DM) pathogenesis. In this review, we discuss how genome-wide association studies …

Genome-wide association analyses have uncovered multiple genomic regions associated
with T2D, but identification of the causal variants at these remains a challenge. There is …