Ageing is a global burden. Increasing age is associated with increased incidence of
infections and cancer and decreased vaccine efficacy. This increased morbidity observed …

A fully functioning immune system is essential in order to maintain good health. However,
the immune system deteriorates with advancing age, and this contributes to increased …

Innate and adaptive immune functions decline with age, leading to increased susceptibility
to infectious diseases and cancer, and reduced responses to preventive vaccination in the …

Infections, cancer and autoimmune diseases occur more frequently in the elderly, and
although many factors contribute to this, the age-related remodelling of the immune system …

Chronic inflammation is the common pathological basis for such age-associated diseases
as cardiovascular disease, diabetes, cancer and Alzheimer's disease. A multitude of bodily …

Significance: With the growing population of baby boomers, there is a great need to
determine the effects of advanced age on the function of the immune system. Recent …

Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

As humans age, their morbidity and mortality from infection increases, their response to
vaccination declines and they have an increased incidence of inflammatory diseases and …

The aging immune system (immunosenescence) has been implicated with increased
morbidity and mortality in the elderly. Of note, T cell aging and low-grade inflammation …

Review of the current understanding of age-dependent changes in leukocyte function and
their contribution to aging-related disease processes. Aging is associated with a progressive …