The blood-brain barrier (BBB) disruption following cerebral ischemia can be exploited to
deliver imaging agents and therapeutics into the brain. The aim of this study was (a) to …

The blood–brain barrier (BBB) disruption following cerebral ischemia (stroke) contributes to
the development of life-threatening brain edema. Recent studies suggested that the …

Impairment of the blood–brain barrier (BBB) after cerebral ischemia leads to extravasation of
plasma constituents into the brain parenchyma. We describe a novel method using non …

Background and Purpose—Detection and localization of the early phase of blood–brain
barrier disruption (BBBD) in vivo during cerebral ischemia/reperfusion injury remain a major …

Objective: This study tested the hypothesis that blood-brain barrier (BBB) opening during
acute reperfusion permits the passage of smaller macromolecules but not larger ones and …

Focal cerebral ischemia is among the main causes of death and disability worldwide. The
ischemic core often progresses, invading the peri-ischemic brain; however, assessing the …

Background and Purpose—Micro–computed tomography (mCT) offers high-resolution
images, but it suffers from low contrast sensitivity and poor soft tissue contrast. We introduce …

Background and Purpose—Animal models of acute cerebral ischemia have demonstrated
that diffuse blood–brain barrier (BBB) disruption can be reversible after early reperfusion …

Ischemic stroke not only impairs neuronal function but also affects the cerebral vasculature
as indicated by loss of blood—brain barrier (BBB) integrity. Therefore, therapeutical …

Background: Since it is known that serum albumin-bound dyes can cross the blood-brain
barrier (BBB) after ischemia, Evans Blue dye is commonly used to assess BBB disruption …