The roles of curcumin in regulating the tumor immunosuppressive microenvironment

Y Wang, J Lu, B Jiang, J Guo - Oncology letters, 2020 - spandidos-publications.com
Cancer is a harmful threat to human health. In addition to surgery, a variety of anticancer
drugs are increasingly used in cancer therapy; however, despite the developments in …

[HTML][HTML] Curcumin enhances anti‑cancer efficacy of either gemcitabine or docetaxel on pancreatic cancer cells

P Liu, Q Ying, H Liu, SQ Yu, LP Bu… - Oncology …, 2020 - spandidos-publications.com
Curcumin is a natural compound extracted from turmeric (Curcuma longa), which has been
reported to be a promising anti‑cancer drug in various human cancers. However, the effects …

Curcumin in cancer therapy: Exploring molecular mechanisms and overcoming clinical challenges

W Wang, M Li, L Wang, L Chen, BC Goh - Cancer Letters, 2023 - Elsevier
Cancer poses a significant global health burden, necessitating the widespread use of
chemotherapy and radiotherapy as conventional frontline interventions. Although targeted …

Nuclear factor‐κB and IκB kinase are constitutively active in human pancreatic cells, and their down‐regulation by curcumin (diferuloylmethane) is associated with the …

L Li, BB Aggarwal, S Shishodia… - … Journal of the …, 2004 - Wiley Online Library
BACKGROUND Pancreatic carcinoma is a lethal malignancy, with the best available
therapeutic option—gemcitabine—yielding response rates of< 10%. Because nuclear factor …

Curcumin targets in inflammation and cancer

A Deguchi - Endocrine, Metabolic & Immune Disorders-Drug …, 2015 - ingentaconnect.com
Curcumin (1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-dione) is commonly
used as a spice, food additive or dietary pigment. Accumulating evidence suggests that …

Curcumin: A therapeutic strategy for colorectal cancer?

VR de Porras, L Layos, E Martínez-Balibrea - Seminars in cancer biology, 2021 - Elsevier
Colorectal cancer (CRC) is the second cause of cancer death worldwide. The metastatic
disease is mainly treated with aggressive therapies consisting on combinations of cytotoxic …

Curcumin as a cancer chemotherapy sensitizing agent

Y Kwon - Journal of the Korean Society for Applied Biological …, 2014 - Springer
The development of cancer chemotherapy made a significant progress in cancer treatment.
However, most chemotherapeutic drugs are challenged by drug resistance and druginduced …

Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer

S Bisht, M Mizuma, G Feldmann, NA Ottenhof… - Molecular cancer …, 2010 - AACR
Curcumin or diferuloylmethane is a yellow polyphenol extracted from the rhizome of turmeric
(Curcuma longa). A large volume (several hundreds) of published reports has established …

Curcumin: preventive and therapeutic properties in laboratory studies and clinical trials

AS Strimpakos, RA Sharma - Antioxidants & redox signaling, 2008 - liebertpub.com
Curcumin is a natural polyphenol used in ancient Asian medicine. Since the first article
referring to the use of curcumin to treat human disease was published in The Lancet in …

Perspectives on chemopreventive and therapeutic potential of curcumin analogs in medicinal chemistry

S Padhye, D Chavan, S Pandey… - Mini reviews in …, 2010 - ingentaconnect.com
Curcumin is a natural polyphenol derived from the plant Curcuma longa, commonly called
turmeric. Extensive research over past 50 years has indicated that this polyphenol is highly …