Curcumin and cancer biology: Focusing regulatory effects in different signalling pathways

M Bhatia, M Bhalerao, N Cruz‐Martins… - Phytotherapy …, 2021 - Wiley Online Library
Cancer is the second‐leading cause of death worldwide. Till date, many such effective
treatments are available, for example chemotherapy, surgery, and radiation therapy, but …

Curcuma as an adjuvant in colorectal cancer treatment

C Villegas, R Perez, O Sterner, I Gonzalez-Chavarria… - Life sciences, 2021 - Elsevier
Colorectal cancer (CRC) is the second leading cause of cancer death worldwide and mostly
affects men. Around 20% of its incidence is by familiar disposition due to hereditary …

The multifaceted role of curcumin in cancer prevention and treatment

MK Shanmugam, G Rane, MM Kanchi, F Arfuso… - Molecules, 2015 - mdpi.com
Despite significant advances in treatment modalities over the last decade, neither the
incidence of the disease nor the mortality due to cancer has altered in the last thirty years …

Liposome‐encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis

L Li, FS Braiteh, R Kurzrock - … international journal of the …, 2005 - Wiley Online Library
BACKGROUND Because a role for nuclear factor‐κB (NF‐κB) has been implicated in the
pathogenesis of pancreatic carcinoma, this transcription factor is a potential target for the …

An update on the pharmacological usage of curcumin: has it failed in the drug discovery pipeline?

F Olotu, C Agoni, O Soremekun… - Cell Biochemistry and …, 2020 - Springer
The pharmacological propensities of curcumin have been reported in a plethora of pre-
clinical and clinical studies. However, innate attributes account for extremely low oral …

C086, a novel analog of curcumin, induces growth inhibition and down-regulation of NFκB in colon cancer cells and xenograft tumors

C Chen, Y Liu, Y Chen, J Xu - Cancer biology & therapy, 2011 - Taylor & Francis
New analogues of curcumin with improved properties are needed to meet therapeutic
requirements. In this study, the effects of C086 on growth inhibition and NFκB pathway …

Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy

M Mimeault, SK Batra - Chinese medicine, 2011 - Springer
Curcumin has attracted great attention in the therapeutic arsenal in clinical oncology due to
its chemopreventive, antitumoral, radiosensibilizing and chemosensibilizing activities …

Curcumin and its analogues: potential anticancer agents

DK Agrawal, PK Mishra - Medicinal research reviews, 2010 - Wiley Online Library
This review chronicles the exploration of the curcumin in terms of development of analogues
for the anticancer activity over the last century. Curcumin is a natural phytochemical …

Curcumin for chemoprevention of colon cancer

JJ Johnson, H Mukhtar - Cancer letters, 2007 - Elsevier
The most practical approach to reduce the morbidity and mortality of cancer is to delay the
process of carcinogenesis through the use of chemopreventive agents. This necessitates …

Curcumin and cancer: barriers to obtaining a health claim

JG Devassy, ID Nwachukwu, PJH Jones - Nutrition reviews, 2015 - academic.oup.com
Curcumin is a highly pleiotropic molecule found in the rhizomes of Curcuma longa
(turmeric). It is responsible for the yellow color of turmeric and has been shown to inhibit the …