Endothelial dysfunction and vascular disease

PM Vanhoutte, H Shimokawa, EHC Tang… - Acta …, 2009 - Wiley Online Library
The endothelium can evoke relaxations (dilatations) of the underlying vascular smooth
muscle, by releasing vasodilator substances. The best characterized endothelium‐derived …

Endothelial dysfunction and vascular disease–a 30th anniversary update

PM Vanhoutte, H Shimokawa, M Feletou… - Acta …, 2017 - Wiley Online Library
The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

Endothelial dysfunction and atherosclerosis

PM Vanhoutte - European heart journal, 1997 - academic.oup.com
The endothelium mediates a number of responses (relaxation or contraction) of arteries and
veins from animals and humans. The endothelium-dependent relaxations are due to the …

Endothelial dysfunction the first step toward coronary arteriosclerosis

PM Vanhoutte - Circulation Journal, 2009 - jstage.jst.go.jp
The endothelium causes relaxations of the underlying vascular smooth muscle, by releasing
nitric oxide (NO). The endothelial cells also can evoke hyperpolarization of the vascular …

Endothelial dysfunction in human disease

H Drexler, B Hornig - Journal of molecular and cellular cardiology, 1999 - Elsevier
The vascular endothelium plays a key role in the local regulation of vascular tone by the
release of vasodilator substances (ie endothelium-derived relaxing factor (EDRF= nitric …

Endothelial dysfunction: from physiology to therapy

JV Mombouli, PM Vanhoutte - Journal of molecular and cellular cardiology, 1999 - Elsevier
The endothelium controls the tone of the underlying vascular smooth muscle mainly through
the production of vasodilator mediators. In some cases, this function is hampered by the …

Human endothelial dysfunction: EDRFs

AJ Flammer, TF Lüscher - Pflügers Archiv-European Journal of Physiology, 2010 - Springer
Since the detection of nitric oxide two and a half decades ago, there has been an incredible
boost in endothelial function research, which is fascinating the research community …

Secondary endothelial dysfunction: hypertension and heart failure

CM Boulanger - Journal of molecular and cellular cardiology, 1999 - Elsevier
The endothelium is a major regulator of vascular tone, releasing vasoactive substances
such as endothelium-derived nitric oxide (EDRF), endothelium-derived hyperpolarizing …

Endothelium-derived vasoactive substances: potential role in hypertension, atherosclerosis, and vascular occlusion

TF Lüscher, Z Yang, D Diederich… - Journal of …, 1989 - journals.lww.com
The endothelium can profoundly affect vascular tone by releasing endothelium-derived
relaxing and contracting factors. Nitric oxide (EDRF) is the most important relaxing factor that …

Endothelial dysfunction in hypertension

H Shimokawa - Journal of atherosclerosis and thrombosis, 1998 - jstage.jst.go.jp
The endothelium modulates the tone of the underlying vascular smooth muscle by releasing
relaxing factors, including prostacyclin, nitric oxide (NO), and endothelium-derived …