Lens epithelial cell apoptosis is an early event in the development of UVB-induced cataract

WC Li, A Spector - Free Radical Biology and Medicine, 1996 - Elsevier
Epidemiological and experimental studies have revealed that exposure to UV can induce
cataractogenesis. To investigate the mechanism of this induction, viability of the lens …

Apoptotic and necrotic mechanisms of stress-induced human lens epithelial cell death

AC Long, CMH Colitz… - Experimental biology and …, 2004 - journals.sagepub.com
Exposure to ultraviolet radiation (UVR) and reactive oxygen species (ROS) can damage the
human lens and contribute to cataract formation. Recent evidence suggests that apoptosis in …

Morphological observation on cell death and phagocytosis induced by ultraviolet irradiation in a cultured human lens epithelial cell line

YB Shui, H Sasaki, JH Pan, I Hata, M Kojima… - Experimental eye …, 2000 - Elsevier
The purpose of this study is to observe dynamic morphological changes induced by
ultraviolet (UV) irradiation in a cultured human lens epithelial cell line using electron …

[HTML][HTML] p53 expression and apoptosis in the lens after ultraviolet radiation exposure

M Ayala, H Strid, U Jacobsson… - … ophthalmology & visual …, 2007 - arvojournals.org
purpose. To localize p53 protein and active caspase-3 in the albino rat lens and to compare
p53 mRNA and active caspase-3 expression in ultraviolet radiation (UVR) 300 nm exposed …

DNA damage and repair in rabbit lens epithelial cells following UVA radiation

D Sidjanin, S Zigman, J Reddan - Current eye research, 1993 - Taylor & Francis
Since ultraviolet light may be a contributing factor to cataractogenesis, we investigated the
response of the lens epithelium, a potential target for W insult, to WA radiation, Cell survival …

Lens epithelium: a primary target of UVB irradiation

KR Hightower, JR Reddan, JP McCready… - Experimental eye …, 1994 - Elsevier
Cultured rabbit lenses and cultured rabbit lens epithelial cells were irradiated with UV to
correlate morphological changes in the epithelium with physiological changes in the whole …

Evolution of damage in the lens after in vivo close to threshold exposure to UV-B radiation: cytomorphological study of apoptosis

K Galichanin, S Löfgren, J Bergmanson… - Experimental eye …, 2010 - Elsevier
The purpose of the present study was to investigate cataractogenesis and recovery of lens
damage after in vivo close to threshold ultraviolet (UV)-B radiation around 300nm. Eighty six …

Apoptosis in the rat lens after in vivo threshold dose ultraviolet irradiation.

R Michael, GF Vrensen, J Van Marle… - … & visual science, 1998 - iovs.arvojournals.org
PURPOSE: To investigate DNA damage in the rat lens after in vivo close-to-threshold
exposure to ultraviolet radiation (UVR). METHODS: Sprague-Dawley rats received 5 kJ/m2 …

Lens epithelial cell apoptosis appears to be a common cellular basis for non-congenital cataract development in humans and animals.

WC Li, JR Kuszak, K Dunn, RR Wang, W Ma… - The Journal of cell …, 1995 - rupress.org
Cataract is a major ocular disease that causes blindness in many developing countries of
the world. It is well established that various factors such as oxidative stress, UV, and other …

The mechanism of UVB irradiation induced-apoptosis in cataract

Y Ji, L Cai, T Zheng, H Ye, X Rong, J Rao… - Molecular and Cellular …, 2015 - Springer
Cataract is the most common eye disease that causes blindness in patients. Ultraviolet B
(UVB) irradiation is considered an important factor leading to cataract by inducing apoptosis …