The interaction of carbon dioxide and hypoxia in the control of cerebral blood flow

A Mardimae, DY Balaban, MA Machina, JS Han… - … -European Journal of …, 2012 - Springer
Both hypoxia and carbon dioxide increase cerebral blood flow (CBF), and their effective
interaction is currently thought to be additive. Our objective was to test this hypothesis. Eight …

Intermittent hypoxia enhances shear-mediated dilation of the internal carotid artery in young adults

E Iwamoto, BE Hanson, JM Bock… - Journal of Applied …, 2020 - journals.physiology.org
Cyclic intermittent hypoxia (IH) increases cerebral blood velocity. This enhanced velocity
augments the commensurate shear stimulus and may subsequently increase …

Heterogeneities of regional cerebral blood flow during hypoxia-ischemia in the rat.

MD Ginsberg, R Medoff, M Reivich - Stroke, 1976 - Am Heart Assoc
The distribution of regional cerebral blood flow (rCBF) within the cerebral hemispheres of
rats was investigated following an hypoxic-ischemic insult consisting of a 30-minute …

Role of large arteries in regulation of cerebral blood flow in dogs

DD Heistad, ML Marcus… - The Journal of clinical …, 1978 - Am Soc Clin Investig
Previous studies have demonstrated a significant pressure gradient from carotid artery to
pial or middle cerebral arteries. This pressure gradient suggests that large cerebral arteries …

The influence of oxygen tension on membrane potential and tone of canine carotid artery smooth muscle

J Grote, G Siegel, K Zimmer, A Adler - Oxygen Transport to Tissue X, 1988 - Springer
During arterial hypoxia the brain blood flow rate increases when oxygen tensions below
approximately 60 mmHg are attained (Betz, 1972; Grote and Schubert, 1982; Kuschinsky …

Augmented hypoxic cerebral vasodilation in men during 5 days at 3,810 m altitude

JB Jensen, B Sperling… - Journal of Applied …, 1996 - journals.physiology.org
The fractional increase in cerebral blood flow (CBF) velocity (VCBF) from the control value
with 5-min steps of isocapnic hypoxia and hyperoxic hypercapnia was measured by …

Protocol to measure acute cerebrovascular and ventilatory responses to isocapnic hypoxia in humans

JC Kolb, PN Ainslie, K Ide, MJ Poulin - Respiratory physiology & …, 2004 - Elsevier
This study describes a protocol to determine acute cerebrovascular and ventilatory (AHVR)
responses to hypoxia. Thirteen subjects undertook a protocol twice, 5 days apart. The …

Characteristics of reactive hyperemia in the cerebral circulation

JK Gourley, DD Heistad - American Journal of Physiology …, 1984 - journals.physiology.org
Reactive hyperemia has been characterized in many vascular beds, but little is known about
quantitative characteristics of reactive hyperemia in the cerebral circulation. We measured …

Cerebral blood flow and cerebral oxygen consumption during hypothermia

HL Rosomoff, DA Holaday - American Journal of …, 1954 - journals.physiology.org
METHODS Nineteen mongrel dogs, weighing between 8.5 and I 2.9 kg and unselected as to
age and sex, were used in this investigation. Cerebral Blood Flow. The nitrous oxide and …

Alterations in cerebral blood flow and cerebrovascular reactivity during 14 days at 5050 m

SJE Lucas, KR Burgess, KN Thomas… - The Journal of …, 2011 - Wiley Online Library
Non‐technical summary Brain blood flow increases during the first week of living at high
altitude. We do not understand completely what causes the increase or how the factors that …