Influence of cerebrovascular function on the hypercapnic ventilatory response in healthy humans

A Xie, JB Skatrud, B Morgan, B Chenuel… - The Journal of …, 2006 - Wiley Online Library
An important determinant of [H+] in the environment of the central chemoreceptors is
cerebral blood flow. Accordingly we hypothesized that a reduction of brain perfusion or a …

Renormalization of regional brain blood flow during prolonged mild hypoxic exposure in rats

K Xu, MA Puchowicz, JC LaManna - Brain research, 2004 - Elsevier
In this study, we measured regional brain blood flow (BF) in rats during hypoxic exposure.
Our data show the hypoxia-induced brain blood flow increase returned to baseline within 1 …

Vascular reactivity in middle cerebral artery and basilar artery by transcranial Doppler in normals subjects during hypoxia

L Garbin, F Habetswallner, A Clivati - The Italian Journal of Neurological …, 1997 - Springer
The anatomical and physiological differences between the carotid and vertebrobasilar
circulations suggest the possibility of a different response to variations in systemic pO 2. We …

Cerebral blood flow responses to changes in oxygen and carbon dioxide in humans

A Vovk, DA Cunningham, JM Kowalchuk… - Canadian journal of …, 2002 - cdnsciencepub.com
This study characterized cerebral blood flow (CBF) responses in the middle cerebral artery
to P CO2ranging from 30 to 60 mmHg (1 mmHg= 133.322 Pa) during hypoxia (50 mmHg) …

Fundamental importance of arterial oxygen content in the regulation of cerebral blood flow in man

MM BROWN, JPH Wade, J MARSHALL - Brain, 1985 - academic.oup.com
The relationships between cerebral blood flow (CBF), arterial oxygen content, whole blood
viscosity and the transport of oxygen to the brain have been studied in 54 subjects with …

A brief episode of severe arterial hypertension induces delayed deterioration of brain function and worsens blood flow after transient multifocal cerebral ischemia.

AJ Dutka, JM Hallenbeck, P Kochanek - Stroke, 1987 - Am Heart Assoc
Transient arterial hypertension occurs sporadically following cerebral air embolism and may
occur during the acute phase of stroke. This study used an animal model of multifocal …

Unexpected reductions in regional cerebral perfusion during prolonged hypoxia

JS Lawley, JH Macdonald, SJ Oliver… - The Journal of …, 2017 - Wiley Online Library
Key points Cognitive performance is impaired by hypoxia despite global cerebral oxygen
delivery and metabolism being maintained. Using arterial spin labelled (ASL) magnetic …

Cerebral ischaemia induced by bilateral carotid occlusion in spontaneously hypertensive rats: Supra-and infratentorial metabolism and arterial acid-base balance

M Fujishima, Y Nakatomi, K Tamaki, J Ogata… - Journal of the …, 1977 - Elsevier
Following bilateral carotid occlusion in spontaneously hypertensive rats (SHR), the
supratentorial tissue lactate and lactate/pyruvate (L/P) ratio increased and ATP …

Interaction of hypoxia and hypercapnia on cerebral hemodynamics and brain electrical activity in dogs

RW McPherson, D Eimerl… - American Journal of …, 1987 - journals.physiology.org
The interaction of hypoxic hypoxia, hypercapnia, and mean arterial blood pressure (MABP)
was studied in 15 pentobarbital-anesthetized ventilated dogs. In one group of animals (n= 5) …

Effects of anesthesia on cerebral arteriolar responses to hypercapnia

JE Levasseur, HA Kontos - American Journal of Physiology …, 1989 - journals.physiology.org
We evaluated the effect of general anesthesia induced by 45 mg/kg iv pentobarbital sodium
or by 75 mg/kg iv alpha-chloralose plus 500 mg/kg iv urethan on the response of cerebral …