We evaluated the rate of second malignancies in 1205 patients with osteosarcoma of the
extremity treated at our Institution with different protocols of adjuvant and neoadjuvant …

Medical records of 133 patients, 10 years old or younger with primary high-grade
nonmetastatic osteosarcoma of the extremities treated at the Rizzoli Institute between 1983 …

Purpose The aim of this study was to compare the results in terms of histologic response to
primary chemotherapy of two sequential studies in osteosarcoma patients preoperatively …

Background Osteosarcoma as second malignancy of childhood cancers rarely occurs, and
its clinical characteristics are unclear. Methods Patients with osteosarcoma occurring as …

PURPOSE The specific aims of this study were to improve event-free survival (EFS) in
patients with newly diagnosed nonmetastatic osteosarcoma of an extremity using the …

Purpose: Successful therapeutic interventions to prevent disease progression in patients
with nonmetastatic osteosarcoma have included surgery with adjuvant chemotherapy …

To investigate the incidence and outcome of secondary neoplasms in pediatric patients
treated for childhood cancer. Between December 1971 and January 2000, a total of 5859 …

Purpose Relapse remains a significant problem in patients with metastatic osteosarcoma.
The response to carboplatin of patients with newly diagnosed metastatic or unresectable …

PURPOSE AND METHODS Between January 1981 and June 1993, 137 children and
adolescents were each treated at the Institut Gustave Roussy for an initially nonmetastatic …

Background In osteosarcoma, as in other tumors, the presence of metastases at
presentation is generally considered a consequence of late diagnosis. To verify this, the …