Chondrocytes, which are the only cell type in the articular cartilage, show substantial
morphological and functional differences, depending on their location within the tissue. In …

Mechanical stress damage and insufficient self-repair can contribute to osteoarthritis (OA) in
the affected joint. As the effects of stress on chondrocyte metabolism can regulate cartilage …

Cell death with morphological and molecular features of apoptosis has been detected in
osteoarthritic (OA) cartilage, which suggests a key role for chondrocyte death/survival in the …

Musculoskeletal conditions are a major burden on individuals, healthcare systems, and
social care systems throughout the world, with indirect costs having a predominant …

Osteoarthritis (OA) is a whole joint disease, in which thinning and disappearance of cartilage
is a critical determinant in OA progression. The rupture of cartilage homeostasis whatever its …

Structural damage of cartilage and bone tissue is a hallmark of rheumatoid arthritis (RA).
The resulting joint destruction constitutes one of the major disease consequences for …

Key Points Osteoarthritis (OA) is one of the most chronic health disorders in the western
world and becomes particularly common with advanced age. The joints most commonly …

Osteoarthritis (OA) is a whole joint disease driven by abnormal biomechanics and attendant
cell-derived and tissue-derived factors. The disease is multifactorial and polygenic, and its …

In adult healthy cartilage, chondrocytes are in a quiescent phase characterized by a fine
balance between anabolic and catabolic activities. In ageing, degenerative joint diseases …

Osteoarthritis (OA) is a progressive and disabling disease resulting from a combination of
risk factors, including advancing age, genetics, trauma, knee malalignment, increased …