Articular cartilage extracellular matrix and cell function change with age and are considered
to be the most important factors in the development and progression of osteoarthritis. The …

Osteoarthritis (OA) is a disease of the entire joint. Different treatment strategies for OA have
been proposed and tested clinically without the desired efficacy. One reason for the scarcity …

OBJECTIVE: Age-related changes in multiple components of the musculoskeletal system
may contribute to the well established link between aging and osteoarthritis (OA). This …

Osteoarthritis (OA) is a chronic, progressive degenerative whole joint disease that affects the
articular cartilage, subchondral bone, ligaments, capsule, and synovium. While it is still …

Osteoarthritis (OA) is a common debilitating joint disorder, affecting large sections of the
population with significant disability and impaired quality of life. During OA, functional units …

The prevalence of Osteoarthritis (OA) is increasing because of the progressive aging and
unhealthy lifestyle. These risk factors trigger OA by removing constraints that keep the tightly …

Chondrocytes are the main cell type in articular cartilage. They are embedded in an
avascular, abundant, and specialized extracellular matrix (ECM). Chondrocytes are …

Knee injuries such as anterior cruciate liamgent ruptures and meniscal injury are common
and are most frequently sustained by young and active individuals. Knee injuries will lead to …

Background Traumatic knee injuries in humans trigger an immediate increase in synovial
fluid levels of inflammatory cytokines that accompany impact damage to joint tissues. We …

Purpose This manuscript will summarize the role of pro-inflammatory cytokines and tackle
newly discussed ones within the scope of OA pathogenesis as mentioned in the recent …