Covering: 1990 to 2009 Fungi have emerged worldwide as increasingly frequent causes of
healthcare-associated infections, but fungal infections have generally been considered …

Highlights•Natural products play a crucial role in antifungal drug discovery.•Natural products
represent many first-in-class antifungal agents in clinical trials with new modes of …

Nosocomial infections caused by fungi have increased greatly in recent years, mainly due to
the rising number of immunocompromised patients. However, the available antifungal …

Introduction: Superficial infections involving the skin and mucosa are the most common
fungal disease in humans. Fungi can also produce invasive infections (IFI), which are …

The vast number and variety of chemotherapeutic agents isolated from microbial natural
products and used to treat bacterial infections have greatly contributed to the improvement of …

Invasive fungal infections are becoming an increasingly important cause of human mortality
and morbidity, particularly for immunocompromised populations. The fungal pathogens …

Due to their eukaryotic heritage, the differences between a fungal pathogen's molecular
makeup and its human host are small. Therefore, the discovery and subsequent …

The need for new antifungal agents continues, fueled by opportunistic infections in
immunecompromised patients and by the development of resistance to existing agents …

In recent years, incidences of invasive fungal infections have greatly increased, especially in
immunosuppressed patients, but most today's antifungal drugs are not completely effective …

Fungi are eukaryotic microorganisms that are closely related to humans at cellular level.
Human fungal pathogens belong to various classes of fungi, mainly zygo-cetes …