Interleukin (IL)-11 is upregulated in a wide variety of fibro-inflammatory diseases such as
systemic sclerosis, rheumatoid arthritis, pulmonary fibrosis, inflammatory bowel disease …

Abstract Interleukin-11 (IL-11) is a cytokine that has been strongly implicated in the
pathogenesis of fibrotic diseases and solid malignancies. Elevated IL-11 expression is also …

The cytokine IL-10 is a key anti-inflammatory mediator ensuring protection of a host from
over-exuberant responses to pathogens and microbiota, while playing important roles in …

Fibrosis affects all vital organs accounting for a staggering 45% of deaths worldwide and no
effective therapies are currently available. Unresolved inflammation triggers downstream …

Significance: Fibrosis is the endpoint of chronic disease in multiple organs, including the
skin, heart, lungs, intestine, liver, and kidneys. Pathologic accumulation of fibrotic tissue …

Fibrosis is a detrimental outcome of most chronic inflammatory disorders and is defined by
the buildup of excess extracellular matrix (ECM) components, which eventually leads to …

Abstract Interleukin 6 (IL-6) has a broad effect on cells of the immune system and those not
of the immune system and often displays hormone-like characteristics that affect homeostatic …

Interleukin 11 (IL11) is upregulated in inflammatory conditions, where it is mostly believed to
have anti-inflammatory activity. However, recent studies suggest instead that IL11 promotes …

Interleukin 6 (IL-6) is a 184-amino acid protein cytokine that is produced by many types of
cells and is expressed during states of cellular stress, such as inflammation, infection …

IL-6 has been linked to numerous diseases associated with inflammation, including
rheumatoid arthritis, inflammatory bowel disease, vasculitis and several types of cancer …