Fractalkine receptor (CX3CR1)‐deficient mice develop very severe experimental
autoimmune encephalomyelitis (EAE), associated with impaired NK cell recruitment into the …

Leukocyte trafficking to the central nervous system (CNS), regulated in part by chemokines,
determines severity of the demyelinating diseases multiple sclerosis (MS) and experimental …

Multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous
system (CNS) is the leading cause of non-traumatic neurological disability in young adults …

Fractalkine, a chemokine anchored to neurons or peripheral endothelial cells, serves as an
adhesion molecule or as a soluble chemoattractant. Fractalkine binds CX3CR1 on microglia …

Neuronal fractalkine acts via its receptor, CX3CR1, on microglia to regulate
neuroinflammation. Conflicting results have been reported in studies employing CX3CR1 …

Immunosenescence, or ageing of the immune system, contributes to the increased morbidity
and mortality seen in the elderly population. Premature immunosenescence is shown to …

The nonneural cholinergic system of immune cells is pivotal for the maintenance of
immunological homeostasis. Here we demonstrate the expression of choline …

T cells continuously sample CNS-derived antigens in the periphery, yet it is unknown how
they sample and respond to CNS antigens derived from distinct brain areas. We expressed …

Invariant NKT cells are CD1d-restricted T cells specific for glycolipid Ags. Their activation or
transgenic enrichment abrogates the development of experimental autoimmune …

Dendritic cells (DCs)—although absent from the healthy CNS parenchyma—rapidly
accumulate within brain and spinal cord tissue during neuroinflammation associated with …