[PDF][PDF] RNA exosome-regulated long non-coding RNA transcription controls super-enhancer activity
We have ablated the cellular RNA degradation machinery in differentiated B cells and
pluripotent embryonic stem cells (ESCs) by conditional mutagenesis of core (Exosc3) and …
pluripotent embryonic stem cells (ESCs) by conditional mutagenesis of core (Exosc3) and …
[HTML][HTML] Long noncoding RNAs usher in a new era in the biology of enhancers
UA Ørom, R Shiekhattar - Cell, 2013 - cell.com
Enhancer-associated long noncoding RNAs act over long distances and across
chromosomes to activate transcription at distal promoters. Here, we address the latest …
chromosomes to activate transcription at distal promoters. Here, we address the latest …
The human cap-binding complex is functionally connected to the nuclear RNA exosome
PR Andersen, M Domanski, MS Kristiansen… - Nature structural & …, 2013 - nature.com
Nuclear processing and quality control of eukaryotic RNA is mediated by the RNA exosome,
which is regulated by accessory factors. However, the mechanism of exosome recruitment to …
which is regulated by accessory factors. However, the mechanism of exosome recruitment to …
The regulation and functions of the nuclear RNA exosome complex
The RNA exosome complex is the most versatile RNA-degradation machine in eukaryotes.
The exosome has a central role in several aspects of RNA biogenesis, including RNA …
The exosome has a central role in several aspects of RNA biogenesis, including RNA …
The human nuclear exosome targeting complex is loaded onto newly synthesized RNA to direct early ribonucleolysis
M Lubas, PR Andersen, A Schein, A Dziembowski… - Cell reports, 2015 - cell.com
The RNA exosome complex constitutes the major nuclear eukaryotic 3′-5′ exonuclease.
Outside of nucleoli, the human nucleoplasmic exosome is directed to some of its substrates …
Outside of nucleoli, the human nucleoplasmic exosome is directed to some of its substrates …
[PDF][PDF] Nontemplated nucleotide additions distinguish the small RNA composition in cells from exosomes
Functional biomolecules, including small noncoding RNAs (ncRNAs), are released and
transmitted between mammalian cells via extracellular vesicles (EVs), including endosome …
transmitted between mammalian cells via extracellular vesicles (EVs), including endosome …
Super-lncRNAs: identification of lncRNAs that target super-enhancers via RNA: DNA: DNA triplex formation
B Soibam - Rna, 2017 - rnajournal.cshlp.org
Super-enhancers are characterized by high levels of Mediator binding and are major
contributors to the expression of their associated genes. They exhibit high levels of local …
contributors to the expression of their associated genes. They exhibit high levels of local …
[HTML][HTML] Extracellular vesicle associated long non-coding RNAs functionally enhance cell viability
C Hewson, D Capraro, J Burdach, N Whitaker… - Non-coding RNA …, 2016 - Elsevier
Cells communicate with one another to create microenvironments and share resources. One
avenue by which cells communicate is through the action of exosomes. Exosomes are …
avenue by which cells communicate is through the action of exosomes. Exosomes are …
The RNA exosome promotes transcription termination of backtracked RNA polymerase II
JF Lemay, M Larochelle, S Marguerat… - Nature structural & …, 2014 - nature.com
The exosome is an RNA-decay complex that constantly monitors transcription and
contributes to post-transcriptional turnover of faulty mRNAs. Yet how nuclear RNA …
contributes to post-transcriptional turnover of faulty mRNAs. Yet how nuclear RNA …
Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF
Approximately 75% of the human genome is transcribed, the majority of which does not
encode protein. However, many noncoding RNAs (ncRNAs) are rapidly degraded after …
encode protein. However, many noncoding RNAs (ncRNAs) are rapidly degraded after …