Eukaryotes have two types of spliceosomes, comprised of either major (U1, U2, U4, U5, U6)
or minor (U11, U12, U4atac, U6atac;< 1%) snRNPs. The high conservation of minor introns …

Degradation of transcripts in human nuclei is primarily facilitated by the RNA exosome. To
obtain substrate specificity, the exosome is aided by adaptors; in the nucleoplasm, those …

The embryonic stem cell (ESC) transcriptional and epigenetic networks are controlled by a
multilayer regulatory circuitry, including core transcription factors (TFs), posttranscriptional …

Summary Poly (A)-binding proteins (PABPs) are important to eukaryotic gene expression. In
the nucleus, the PABP PABPN1 is thought to function in polyadenylation of pre-mRNAs …

Long noncoding RNAs (lncRNAs) evolve more rapidly than mRNAs. Whether conserved
lncRNAs undergo conserved processing, localization, and function remains unexplored. We …

The majority of the eukaryotic genome is transcribed into noncoding RNAs (ncRNAs), which
are important regulators of different nuclear processes by controlling chromatin structure …

Understanding the molecular foundations of embryonic stem cell (ESC) self-renewal and
pluripotency will facilitate therapeutic exploitation of these remarkable cells. Here we …

For the last four decades, we have known that noncoding RNAs maintain critical
housekeeping functions such as transcription, RNA processing, and translation. However, in …

A large portion of the human genome is transcribed into RNAs without known protein-coding
functions, far outnumbering coding transcription units. Extensive studies of long noncoding …

Advances in genomics technology over recent years have led to the surprising discovery
that the genome is far more pervasively transcribed than was previously appreciated. Much …