RNA exosome drives early B cell development via noncoding RNA processing mechanisms
B cell development is linked to successful V (D) J recombination, allowing B cell receptor
expression and ultimately antibody secretion for adaptive immunity. Germline noncoding …
expression and ultimately antibody secretion for adaptive immunity. Germline noncoding …
Perspectives on the mechanism of transcriptional regulation by long non-coding RNAs
TC Roberts, KV Morris, MS Weinberg - Epigenetics, 2014 - Taylor & Francis
Long non-coding RNAs (lncRNAs) are increasingly being recognized as epigenetic
regulators of gene transcription. The diversity and complexity of lncRNA genes means that …
regulators of gene transcription. The diversity and complexity of lncRNA genes means that …
Long noncoding RNAs: functional surprises from the RNA world
Most of the eukaryotic genome is transcribed, yielding a complex network of transcripts that
includes tens of thousands of long noncoding RNAs with little or no protein-coding capacity …
includes tens of thousands of long noncoding RNAs with little or no protein-coding capacity …
[PDF][PDF] lncRNA maturation to initiate heterochromatin formation in the nucleolus is required for exit from pluripotency in ESCs
N Savić, D Bär, S Leone, SC Frommel, FA Weber… - Cell stem cell, 2014 - cell.com
The open chromatin of embryonic stem cells (ESCs) condenses into repressive
heterochromatin as cells exit the pluripotent state. How the 3D genome organization is …
heterochromatin as cells exit the pluripotent state. How the 3D genome organization is …
Broad role for YBX1 in defining the small noncoding RNA composition of exosomes
RNA is secreted from cells enclosed within extracellular vesicles (EVs). Defining the RNA
composition of EVs is challenging due to their coisolation with contaminants, lack of …
composition of EVs is challenging due to their coisolation with contaminants, lack of …
[HTML][HTML] Regulation of pluripotency and self-renewal of ESCs through epigenetic-threshold modulation and mRNA pruning
Embryonic stem cell (ESC) pluripotency requires bivalent epigenetic modifications of key
developmental genes regulated by various transcription factors and chromatin-modifying …
developmental genes regulated by various transcription factors and chromatin-modifying …
The RNA exosome and human disease
The evolutionarily conserved RNA exosome is a multisubunit ribonuclease complex that
processes and/or degrades numerous RNAs. Recently, mutations in genes encoding both …
processes and/or degrades numerous RNAs. Recently, mutations in genes encoding both …
RNA exosome depletion reveals transcription upstream of active human promoters
P Preker, J Nielsen, S Kammler, S Lykke-Andersen… - Science, 2008 - science.org
Studies have shown that the bulk of eukaryotic genomes is transcribed. Transcriptome maps
are frequently updated, but low-abundant transcripts have probably gone unnoticed. To …
are frequently updated, but low-abundant transcripts have probably gone unnoticed. To …
CRISPR/Cas9-based generation of knockdown mice by intronic insertion of artificial microRNA using longer single-stranded DNA
H Miura, CB Gurumurthy, T Sato, M Sato, M Ohtsuka - Scientific reports, 2015 - nature.com
Knockdown mouse models, where gene dosages can be modulated, provide valuable
insights into gene function. Typically, such models are generated by embryonic stem (ES) …
insights into gene function. Typically, such models are generated by embryonic stem (ES) …
A post-transcriptional program coordinated by CSDE1 prevents intrinsic neural differentiation of human embryonic stem cells
H Ju Lee, D Bartsch, C Xiao, S Guerrero… - Nature …, 2017 - nature.com
While the transcriptional network of human embryonic stem cells (hESCs) has been
extensively studied, relatively little is known about how post-transcriptional modulations …
extensively studied, relatively little is known about how post-transcriptional modulations …