Transcriptional enhancers are critical for maintaining cell-type–specific gene expression and
driving cell fate changes during development. Highly transcribed genes are often associated …

The exosome is a complex of 3′→ 5′ exoribonucleases which is involved in many RNA
metabolic processes. To regulate these functions distinct proteins are believed to recruit the …

Accessible chromatin is important for RNA polymerase II recruitment and transcription
initiation at eukaryotic promoters. We investigated the mechanistic links between promoter …

The function of microRNAs is well characterized in the cytoplasm, where they direct an
Argonaute-containing complex to target and repress mRNAs. More recently, regulatory roles …

The exosome is a ribonucleolytic complex that plays important roles in RNA metabolism.
Here we show that the exosome is necessary for the repair of DNA double-strand breaks …

Small RNAs derived from mature tRNAs, referred to as tRNA fragments or “tRFs,” are an
emerging class of regulatory RNAs with poorly understood functions. We recently identified …

Long noncoding RNAs (lncRNAs) have been implicated in controlling various aspects of
embryonic stem cell (ESC) biology, although the functions of specific lncRNAs, and the …

Mammalian genomes encode thousands of long noncoding RNAs (lncRNAs) that play
important roles in diverse biological processes. As a class, lncRNAs are generally enriched …

Long non-coding (lnc) RNAs, once thought to merely represent noise from imprecise
transcription initiation, have now emerged as major regulatory entities in all eukaryotes. In …

RNA exosomes are multi-subunit complexes conserved throughout evolution and are
emerging as the major cellular machinery for processing, surveillance and turnover of a …