Selective suppression of AMP-activated protein kinase in skeletal muscle: update on 'lazy mice'

J Mu, ER Barton, MJ Birnbaum - Biochemical Society …, 2003 - portlandpress.com
AMP-activated protein kinase (AMPK) is becoming recognized as a critical regulator of
energy metabolism in cells. Using a mouse model in which we specifically blocked AMPK …

[HTML][HTML] Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat …

JR Hingst, R Kjøbsted, JB Birk, NO Jørgensen… - Molecular …, 2020 - Elsevier
Objective Evidence for AMP-activated protein kinase (AMPK)-mediated regulation of skeletal
muscle metabolism during exercise is mainly based on transgenic mouse models with …

Skeletal muscle AMP-activated protein kinase is essential for the metabolic response to exercise in vivo

RS Lee-Young, SR Griffee, SE Lynes, DP Bracy… - Journal of Biological …, 2009 - ASBMB
AMP-activated protein kinase (AMPK) has been postulated as a super-metabolic regulator,
thought to exert numerous effects on skeletal muscle function, metabolism, and enzymatic …

Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models

B Viollet, F Andreelli, SB Jørgensen… - Biochemical Society …, 2003 - portlandpress.com
AMP-activated protein kinase (AMPK) is viewed as a fuel sensor for glucose and lipid
metabolism. To understand better the physiological role of the catalytic AMPK subunit …

Genetic model for the chronic activation of skeletal muscle AMP-activated protein kinase leads to glycogen accumulation

L Barré, C Richardson, MF Hirshman… - American Journal …, 2007 - journals.physiology.org
The AMP-activated protein kinase (AMPK) is an important metabolic sensor/effector that
coordinates many of the changes in mammalian tissues during variations in energy …

Transgenic models–a scientific tool to understand exercise-induced metabolism: the regulatory role of AMPK (5′-AMP-activated protein kinase) in glucose transport …

JFP Wojtaszewski, JN Nielsen… - Biochemical Society …, 2003 - portlandpress.com
The AMPK (5´ AMP-activated protein kinase) is becoming recognized as a critical regulator
of energy metabolism. However, many of these effects in muscle metabolism have been …

AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling

DR Bolster, SJ Crozier, SR Kimball… - Journal of Biological …, 2002 - ASBMB
AMP-activated protein kinase (AMPK) is viewed as an energy sensor that acts to modulate
glucose uptake and fatty acid oxidation in skeletal muscle. Given that protein synthesis is a …

AMP-activated protein kinase in skeletal muscle: from structure and localization to its role as a master regulator of cellular metabolism

CA Witczak, CG Sharoff, LJ Goodyear - Cellular and Molecular Life …, 2008 - Springer
The AMP-activated protein kinase (AMPK) is a metabolite sensing serine/threonine kinase
that has been termed the master regulator of cellular energy metabolism due to its numerous …

AMP-activated protein kinase regulation and action in skeletal muscle during exercise

N Musi, H Yu, LJ Goodyear - Biochemical Society Transactions, 2003 - portlandpress.com
Physical exercise increases muscle glucose uptake, enhances insulin sensitivity and leads
to fatty acid oxidation in muscle. The AMP-activated protein kinase (AMPK) is an energy …

AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle

J Stoppani, AL Hildebrandt… - American Journal …, 2002 - journals.physiology.org
AMP-activated protein kinase (AMPK) has recently emerged as a key signaling protein in
skeletal muscle, coordinating the activation of both glucose and fatty acid metabolism in …