Inflammation is typically induced in response to a microbial infection. The release of
proinflammatory cytokines enhances the stimulatory capacity of antigen-presenting cells, as …

Type 1 diabetes (T1D) is characterized by the unresolved autoimmune inflammation and
islet β cell destruction. The islet resident antigen-presenting cells (APCs) including dendritic …

Type 1 diabetes (T1D) is an autoimmune disease in which T cells attack and destroy the
insulin-producing β cells in the pancreatic islets. Genetic and environmental factors increase …

Cytokines play crucial roles in orchestrating complex multicellular interactions between
pancreatic β cells and immune cells in the development of type 1 diabetes (T1D) and are …

Islet inflammation (insulitis) in type 1 diabetes mellitus is triggered by a deleterious dialogue
between β-cells and the immune system, inducing β-cell dysfunction and death. This …

Metabolic diseases including type 2 diabetes are associated with meta-inflammation. β-Cell
failure is a major component of the pathogenesis of type 2 diabetes. It is now well …

Type 2 diabetes (T2D) is characterized by a progressive status of chronic, low-grade
inflammation (LGI) that accompanies the whole trajectory of the disease, from its inception to …

Type 1 diabetes is a disorder of immune tolerance that leads to death of insulin-producing
islet β cells. We hypothesize that inflammatory signaling within β cells promotes progression …

Abstract Type 1 diabetes (T1D) is a multi-factorial, organ-specific autoimmune disease in
genetically susceptible individuals, which is characterized by a selective and progressive …

Type one diabetes (T1D) is a complex T cell-mediated autoimmune disease, the defining
feature of which is the destruction of the insulin-secreting beta-(β)-cell. Both genetic and …