Harnessing the power of regulatory T‐cells to control autoimmune diabetes: overview and perspective
H Yu, R Paiva, RA Flavell - Immunology, 2018 - Wiley Online Library
Summary Type 1 diabetes (T1D) is a T‐cell‐mediated autoimmune disease resulting in islet
β‐cell destruction, hypoinsulinaemia and severely altered glucose homeostasis. Although …
β‐cell destruction, hypoinsulinaemia and severely altered glucose homeostasis. Although …
[PDF][PDF] The implication of proinflammatory cytokines in type 2 diabetes
The incidence of type 2 diabetes (T2D) is rapidly expanding. Some of the more obvious
pathologies associated with it include: defective glucose metabolism, obesity …
pathologies associated with it include: defective glucose metabolism, obesity …
The role of β cell stress and neo-epitopes in the immunopathology of type 1 diabetes
JD Piganelli, MJ Mamula, EA James - Frontiers in endocrinology, 2021 - frontiersin.org
Due to their secretory function, β cells are predisposed to higher levels of endoplasmic
reticulum (ER) stress and greater sensitivity to inflammation than other cell types. These …
reticulum (ER) stress and greater sensitivity to inflammation than other cell types. These …
Two to tango: dialogue between adaptive and innate immunity in type 1 diabetes
L Sun, S Xi, G He, Z Li, X Gang, C Sun… - Journal of diabetes …, 2020 - Wiley Online Library
Type 1 diabetes mellitus (T1DM) is a long‐term and chronic autoimmune disorder, in which
the immune system attacks the pancreatic β‐cells. Both adaptive and innate immune …
the immune system attacks the pancreatic β‐cells. Both adaptive and innate immune …
Innate inflammation in type 1 diabetes
SM Cabrera, AM Henschel, MJ Hessner - Translational Research, 2016 - Elsevier
Type 1 diabetes mellitus (T1D) is an autoimmune disease often diagnosed in childhood that
results in pancreatic β-cell destruction and life-long insulin dependence. T1D susceptibility …
results in pancreatic β-cell destruction and life-long insulin dependence. T1D susceptibility …
The immunology of type 1 diabetes
KC Herold, T Delong, AL Perdigoto, N Biru… - Nature Reviews …, 2024 - nature.com
Following the seminal discovery of insulin a century ago, treatment of individuals with type 1
diabetes (T1D) has been largely restricted to efforts to monitor and treat metabolic glucose …
diabetes (T1D) has been largely restricted to efforts to monitor and treat metabolic glucose …
The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis
LE Padgett, KA Broniowska, PA Hansen… - Annals of the New …, 2013 - Wiley Online Library
Type 1 diabetes (T1D) is a T cell–mediated autoimmune disease characterized by the
destruction of insulin‐secreting pancreatic β cells. In humans with T1D and in nonobese …
destruction of insulin‐secreting pancreatic β cells. In humans with T1D and in nonobese …
Pancreatic islet inflammation in type 2 diabetes: from α and β cell compensation to dysfunction
JA Ehses, H Ellingsgaard… - … of physiology and …, 2009 - Taylor & Francis
Evidence in support of the concept of local pancreatic islet inflammation as a mechanism of
β cell failure in type 2 diabetes is accumulating. Observations in human islets from type 2 …
β cell failure in type 2 diabetes is accumulating. Observations in human islets from type 2 …
The case for an autoimmune aetiology of type 1 diabetes
SI Mannering, V Pathiraja… - Clinical & Experimental …, 2016 - academic.oup.com
Summary Type 1 diabetes (T1D) develops when there are insufficient insulin-producing beta
cells to maintain glucose homeostasis. The prevailing view has been that T1D is caused by …
cells to maintain glucose homeostasis. The prevailing view has been that T1D is caused by …
Role of T lymphocytes in type 2 diabetes and diabetes‐associated inflammation
C Xia, X Rao, J Zhong - Journal of diabetes research, 2017 - Wiley Online Library
Although a critical role of adaptive immune system has been confirmed in driving local and
systemic inflammation in type 2 diabetes and promoting insulin resistance, the underlying …
systemic inflammation in type 2 diabetes and promoting insulin resistance, the underlying …