Type 1 diabetes (T1D) is a T cell–mediated autoimmune disease characterized by the
destruction of insulin‐secreting pancreatic β cells. In humans with T1D and in nonobese …

Although a critical role of adaptive immune system has been confirmed in driving local and
systemic inflammation in type 2 diabetes and promoting insulin resistance, the underlying …

At the time of this writing, a major void exists; the lack of a method to prevent and/or reverse
type 1 diabetes in humans. We believe this void to a large extent is the result of our lack in …

The dynamics of CD4+ effector T cells (Teff cells) and CD4+ Foxp3+ regulatory T cells (Treg
cells) during diabetes progression in nonobese diabetic mice was investigated to determine …

Islet autoimmunity has been identified as a component of both type 1 (T1D) and type 2 (T2D)
diabetes, but the pathway through which islet autoimmunity develops in T1D and T2D may …

Inflammation-induced inhibition of the insulin signalling pathway can lead to insulin
resistance and contribute to the development of type 2 diabetes mellitus (T2DM). Obesity …

Type 1 diabetes is characterized by infiltration of pancreatic islets with immune cells, leading
to insulin deficiency. Although infiltrating immune cells are traditionally considered to …

A perplexing feature of type 1 diabetes (T1D) is that the immune system destroys pancreatic
β-cells but not neighbouring α-cells, even though both β-cells and α-cells are dysfunctional …

Genome‐wide association studies (GWAS) have identified more than 50 loci associated with
genetic risk of type 1 diabetes (T1D). Several T1D candidate genes have been suggested or …

Type 1 diabetes mellitus is an autoimmune disease caused by the immune-mediated
destruction of insulin-producing pancreatic beta cells occurring in genetically predisposed …