Prostaglandins are lipid mediators involved in physiological processes, such as constriction
or dilation of blood vessels, but also pathophysiological processes, which include …

There is compelling evidence from animal models of type 1 diabetes (T1D) that the innate
immune system plays a key role in early mechanisms triggering islet destruction. Very little is …

We demonstrate diverse roles of IFN-γ in the induction and regulation of immune-mediated
inflammation using a transfer model of autoimmune diabetes. The diabetogenic CD4+ …

Type 1 diabetes (T1D) results from a complex interplay between genetic susceptibility and
environmental factors that have been implicated in the pathogenesis of disease both as …

Aims/hypothesis The proinflammatory cytokines IFN-α, IFN-γ, IL-1β and TNF-α may
contribute to innate and adaptive immune responses during insulitis in type 1 diabetes and …

Type 1 diabetes (T1D) results from destruction of pancreatic beta cells by T cells of the
immune system. Despite improvements in insulin analogs and continuous blood glucose …

The development of type 1 diabetes involves a complex interaction between pancreatic β-
cells and cells of both the innate and adaptive immune systems. Analyses of the interactions …

Two arms of the immune system, innate and adaptive immunity, differ in their mode of
immune recognition. The innate immune system recognizes a few highly conserved …

Apoptosis of pancreatic β‐cells is the final step in the development of type 1 diabetes (T1D),
leading to critically diminished β‐cell mass and contributing to the onset of hyperglycaemia …

Inflammation plays an important role in the destruction of pancreatic islet β-cells that leads to
type I diabetes. This involves infiltration of T-cells and macrophages into the islets and local …